Haemoglobin synthesis in human fetal liver maintained in short-term tissue culture.

British Journal of Haematology
M Shchory, D J Weatherall

Abstract

Human fetal liver maintained in tissue culture has been examined as a model system for studying the factors involved in the switch from fetal to adult haemoglobin production. In erythropoietin-treated cultures alpha-, beta- and gamma-chain synthesis remains active for up to 12 days. Globin-chain synthesis is balanced and the alpha/beta + gamma-chain production ratio remains constant up to about 8 days; in longer cultures gamma-chain production declines before that of beta chains. It is concluded that the system may be useful for examining factors involved in the switch from gamma- to beta-chain production provided that these are acting on cells already committed to the erythroid compartment.

References

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Jan 1, 1964·Scandinavian Journal of Clinical and Laboratory Investigation·E MYHRE

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Citations

Jan 1, 1978·The International Journal of Biochemistry·B Gradinski-VrbanacS Maricić
May 1, 1977·Journal of Steroid Biochemistry·L F Congote
Dec 29, 1977·The New England Journal of Medicine·A W Nienhuis, E J Benz
Feb 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·P T RowleyB A Farley
Apr 1, 1979·British Journal of Haematology·M W HassanL L Cederqvist
Dec 1, 1977·The British Journal of Addiction to Alcohol and Other Drugs·E Kaufman
Jan 1, 1976·The American Journal of Drug and Alcohol Abuse·E Kaufman
Jan 1, 1982·The American Journal of Drug and Alcohol Abuse·E Kaufman

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