PMID: 2507824Sep 1, 1989Paper

Haemolysis during in vitro CO2 removal from human blood using a membrane lung

Journal of Biomedical Engineering
K M McRae, K L Dorrington

Abstract

Haemolysis of human blood has been examined in vitro as a function of pH in the range 7.2-8.0. The hydrogen ion concentration of freshly donated blood from 11 donors was manipulated in 42 experiments, entirely by altering the carbon dioxide fraction of air with which the blood was equilibrated using a membrane lung. In contrast to the known alkalaemic haemolysis which occurs in canine blood, we observed no correlation between plasma haemoglobin concentrations and blood pH. We conclude that alkalaemic haemolysis is unlikely to complicate the clinical application of extracorporeal carbon dioxide removal in the management of acute respiratory failure.

References

Nov 1, 1977·Anesthesia and Analgesia·R EdwardsS Ramamurthy
Aug 15, 1986·JAMA : the Journal of the American Medical Association·L GattinoniA Agostoni
Jan 16, 1988·British Medical Journal·K L Dorrington
Apr 1, 1985·Journal of Biomedical Engineering·K L DorringtonM K Sykes
Mar 1, 1969·Proceedings of the Society for Experimental Biology and Medicine·P F IampietroR Moses
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Aug 1, 1983·British Journal of Haematology·P V WoolleyE M Bonnem
Feb 1, 1961·British Journal of Anaesthesia·J S ROBINSON

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