Haemolysis following rapid experimental red blood cell transfusion--an evaluation of two infusion pumps

Acta Anaesthesiologica Scandinavica
T G HansenS R Kristensen

Abstract

The vast majority of infusion pumps used for rapid transfusion of large amounts of blood have never been properly examined regarding their influence on the quality of the red blood cells (RBCs) infused. In this study, we evaluated the effect of two different infusion pumps on the degree of RBC destruction following rapid experimental blood transfusion. Divided into 2 groups according to age, 30 u of SAGM RBCs were infused through an experimental transfusion model by either a manual roller pump (MRP) or a pressure infusor pump (PIP). Fresh (i.e stored for 8-11 d) RBCs, 20 u, and 10 u of older (i.e. stored for 25-33 d) RBCs were randomly allocated to infusion with either of the two pumps. The rate of infusion was as fast as possible with the MRP, and with the PIP adjusted with an external applied pressure of 300 mm Hg. RBC samples collected before and after infusion were analyzed for total haemoglobin, free haemoglobin, haematocrit, total free potassium, lactate dehydrogenase (LDH) and the percentage of haemolysis. The time spent for each transfusion was measured by a stop watch. Following infusion, a marginal increase (i.e. considerably below 0.8%) in the percentage of haemolysis and LDH content was seen with both pumps. This in...Continue Reading

References

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Citations

Oct 4, 2003·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Bernhard FreyMarkus Weiss
Dec 31, 2003·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Edward C C WongNaomi L C Luban
Jun 18, 2010·Transfusion Medicine·M J NightingaleD J Pinchon
Aug 18, 2016·Revista latino-americana de enfermagem·Ana Maria Miranda Martins WilsonMavilde da Luz Gonçalves Pedreira
Feb 16, 2017·Vox Sanguinis·T G PoderP Beauregard
Mar 5, 2004·Transfusion·Michal A Miller, Annette J Schlueter
Mar 20, 2008·Anesthesia and Analgesia·Hugh M SmithJuraj Sprung
Oct 24, 2020·Nursing in Critical Care·Larissa Perez PardoMavilde Luz Gonçalves Pedreira

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