Haemolytic crisis of blackwater fever following artemether-lumefantrine intake

Bulletin de la Société de pathologie exotique
N M AloniT F Muanda

Abstract

A second haemolytic crisis of blackwater fever (BWF) following a combination of artemether-lumefantrine intake, in an 8-year-old Congolese boy is reported. The patient had a history of BWF after quinine intake. He was given artemether-lumefantrine treatment for malaria. He was free from G6PD deficiency and abnormal haemoglobin. Sepsis was eliminated. Haemolysis was noted with 5.6 g/dl of haemoglobin, negative direct antiglobulin test, and LDH at 893 IU/l. Low-level Plasmodium falciparum was found. The outcome was favourable with rehydration. BWF has been described with quinine, mefloquine and halofantrine. Several case reports have been published of haemolysis after lumefantrine, but it is quite rare. This case has a major therapeutic implication: aryl-amino-alcohol should be strictly contraindicated in patients with history of BWF with aryl-amino-alcohols intake.

References

May 18, 1996·Lancet·G OrlandoA Cargnel
Sep 15, 1998·Tropical Medicine & International Health : TM & IH·J Van den EndeW Schroyens
Apr 15, 1999·Tropical Medicine & International Health : TM & IH·Z BisoffiM Marsiaj
Dec 29, 2000·Transactions of the Royal Society of Tropical Medicine and Hygiene·R BakshiE Alteri
Oct 31, 2003·Transactions of the Royal Society of Tropical Medicine and Hygiene·Christophe RogierJean-François Trape
Jul 21, 2004·Transactions of the Royal Society of Tropical Medicine and Hygiene·Stéphane MératLouis Brinquin
Oct 16, 2004·Expert Review of Anti-infective Therapy·Walther H Wernsdorfer
Apr 20, 2005·Transactions of the Royal Society of Tropical Medicine and Hygiene·Catherine FaladePatricia Ibarra de Palacios
May 26, 2007·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·A A OumarM M Keita

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Citations

Jul 11, 2013·Current Infectious Disease Reports·Patricia Schlagenhauf, Eskild Petersen
Apr 3, 2012·Malaria Journal·Annemarie R Kreeftmeijer-VegterPeter J de Vries
Sep 5, 2020·Malaria Journal·Peter Olupot-OlupotThomas N Williams
Aug 31, 2012·Acta Paediatrica·Michel N AloniJoseph Mabiala Bodi
Apr 1, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Peter Olupot-OlupotKathryn Maitland

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