PMID: 6401771Jan 1, 1983Paper

Haemolytic-uraemic syndrome complicating long-term mitomycin C and 5-fluorouracil therapy for gastric carcinoma

Journal of Clinical Pathology
J Crocker, E L Jones

Abstract

Three cases of acute renal toxicity in patients receiving long-term therapy with mitomycin C and 5-fluorouracil are reported. Two of the patients (1 and 3) are from a multicentre trial of adjuvant chemotherapy for gastric carcinoma. All three cases showed extensive fibrin deposition in the kidneys and lungs, the appearances of the renal lesions being similar to those seen in the haemolytic-uraemic syndrome. Two of the three cases had received blood transfusions, and attention is drawn to the possibility that mitomycin C may sensitise the kidneys to minor mismatches. With the increasing use of these antimitotic agents, great vigilance should be exercised with regard to renal function and haemolytic status.

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Citations

Apr 2, 2013·The Urologic Clinics of North America·Joshua G Griffin, Jeff Holzbeierlein
Jun 16, 2006·Kidney International·N BesbasUNKNOWN European Paediatric Research Group for HUS
Jan 1, 1987·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J VerweijH M Pinedo
Feb 1, 1987·European Journal of Cancer & Clinical Oncology·J VerweyH M Pinedo
Dec 15, 1988·Biochemical Pharmacology·A DuperrayD Cordonnier
Feb 14, 2006·Seminars in Oncology·Nasir ShahabDonald C Doll
Feb 29, 2000·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·S MollV Nickeleit
Jan 29, 2011·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Rolf BambauerRalf Schiel
Jul 1, 1989·DICP : the Annals of Pharmacotherapy·S M Fields, C M Lindley

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