Haemolytic uraemic syndrome during shigellosis

Transactions of the Royal Society of Tropical Medicine and Hygiene
Thomas Butler

Abstract

Haemolytic uraemic syndrome (HUS), which is comprised of the triad of haemolytic anemia, thrombocytopenia and renal insufficiency, occurs in about 13% of dysenteric patients with shigellosis due to Shigella dysenteriae type 1 (SD1) infections, who are mostly children less than five years old in Africa and Asia. With a case-fatality rate of about 36%, it is the leading cause of death in SD1 outbreaks. Research suggests that Shiga toxin and lipopolysaccharide from the causative bacteria play roles in pathogenesis. The risk of HUS is increased when inappropriate antimicrobial drugs, against which infecting bacteria are resistant, are used or when any antimicrobial drug is given more than four days after the start of diarrhoea. To prevent HUS, it is advised to initiate an appropriate drug early and to consider withholding antimicrobial therapy in patients presenting more than four days after the onset of diarrhoea.

References

Apr 27, 1978·The New England Journal of Medicine·F KosterR C Williams
Dec 1, 1991·The American Journal of Tropical Medicine and Hygiene·S K BhattacharyaS C Pal
May 1, 1991·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·R N SrivastavaA S Vasudev
Nov 1, 1989·The Pediatric Infectious Disease Journal·T ButlerM Islam
Jun 1, 1987·The Journal of Pediatrics·T ButlerP K Jones
Jul 1, 1973·The Journal of Pediatrics·K C Ullis, R M Rosenblatt
Dec 1, 1984·The Journal of Infectious Diseases·P SpeelmanM Islam
Apr 1, 1994·Scandinavian Journal of Gastroenterology·A N AlamH K Hye
Oct 1, 1995·Journal of Tropical Pediatrics·N C RollinsA W Sturm
Apr 1, 1997·Infection and Immunity·D SuJ Levin
Nov 5, 1997·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·R BhimmaM Adhikari
Jan 17, 2002·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·M OnekoE Doehring
Dec 19, 2002·The Pediatric Infectious Disease Journal·UNKNOWN Zimbabwe, Bangladesh, South Africa (Zimbasa) Dysentery Study Group
Jun 25, 2003·Current Opinion in Infectious Diseases·Theresa J Ochoa, Thomas G Cleary
May 6, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Véronique HoudouinEdouard Bingen
Oct 19, 2004·Clinical Microbiology Reviews·Saul TziporiHoward Trachtman
Mar 23, 2005·Lancet·Phillip I TarrWayne L Chandler
Sep 15, 2005·Journal of Medical Microbiology·Neelam TanejaMeera Sharma
Jan 5, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Michael L BennishEdward T Ryan
Jan 5, 2008·Indian Journal of Pediatrics·Ramesh R PolVinod H Ratageri
Jul 17, 2008·Tropical Doctor·Ally Ibrahim OlotuC R J C Newton
Oct 16, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·L Hannah GouldPatricia M Griffin
Jan 15, 2010·Indian Journal of Pediatrics·Arun K BaranwalRupa Singh
Apr 2, 2010·International Journal of Epidemiology·Beatrix S TraaRobert E Black

❮ Previous
Next ❯

Citations

Aug 12, 2014·Current Tropical Medicine Reports·Mussaret Bano Zaidi, Teresa Estrada-García
Mar 18, 2016·Emerging Infectious Diseases·Katherine LambaDuc J Vugia
Oct 21, 2015·Open Forum Infectious Diseases·Miranda D GrayAnthony T Maurelli
May 20, 2015·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·M D GrayA T Maurelli
Jul 6, 2016·Kidney International·Masayuki OzakiGregory L Stahl
Oct 11, 2016·Journal of Internal Medicine·Diana KarpmanIda Arvidsson
Jun 19, 2015·Clinical Microbiology Reviews·Laura Cooling
Oct 5, 2013·Clinical Microbiology Reviews·Matthew A CroxenB Brett Finlay
Jan 9, 2015·Clinical Microbiology Reviews·Romney M Humphries, Andrea J Linscott
Jan 25, 2020·Toxins·Adrien JosephAlexandre Hertig
Oct 11, 2019·F1000Research·Neil S Sheerin, Emily Glover
Feb 21, 2021·Radiología·M Á Corral de la Calle, J Encinas de la Iglesia

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Allergy & Infectious Diseases (ASM)

Allergies result from the hyperreactivity of the immune system to some environmental substance and can be life-threatening. Infectious diseases are caused by organisms including bacteria, viruses, fungi and parasites. They can be transmitted different ways, such as person-to-person. Here is the latest research on allergy and infectious diseases.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Allergy & Infectious Diseases

Allergies result from the hyperreactivity of the immune system to some environmental substance and can be life-threatening. Infectious diseases are caused by organisms including bacteria, viruses, fungi and parasites. They can be transmitted different ways, such as person-to-person. Here is the latest research on allergy and infectious diseases.