Haemophiliacs with factor VIII inhibitors in Finland: prevalence, incidence and outcome

British Journal of Haematology
V Rasi, E Ikkala

Abstract

Twenty-five of the 139 Finnish patients (18.0%) with severe haemophilia A alive in 1960 or born later have or have had an inhibitor against factor VIII. 19 of the 110 patients alive have an inhibitor and the current prevalence is 17.3%. The incidence of new inhibitors was 10.3 per thousand patient years for the observation period starting from 1960, median 16 years. The age dependent cumulative risk of developing an inhibitor was 22% at the age of 10. There have been no deaths from bleeding since 1976, which has resulted in a marked decrease in mortality. The annual death rate of patients with inhibitors was 5.8 per thousand years of life in 1980-89 compared to 41.7 in the previous decade. The recent progress in the modalities for treatment of bleedings has markedly improved the outcome of patients with factor VIII inhibitors.

References

Jan 1, 1989·British Journal of Haematology·F R RosendaalE Briët
Apr 1, 1985·British Journal of Haematology·S A Larsson
Jan 1, 1971·Scandinavian Journal of Haematology·E Ikkala, O Simonen
Oct 16, 1969·The New England Journal of Medicine·H S Strauss
Oct 1, 1959·British Journal of Haematology·R BIGGS, E BIDWELL
Jan 1, 1960·Scandinavian Journal of Clinical and Laboratory Investigation·A RANDRUP

❮ Previous
Next ❯

Citations

Jun 3, 1999·British Journal of Haematology·C R Hay
Jan 5, 1999·Haemophilia : the Official Journal of the World Federation of Hemophilia·I R Walker, J A Julian
Aug 12, 1999·Haemophilia : the Official Journal of the World Federation of Hemophilia·I ScharrerO Neutzling
Mar 22, 2001·Haemophilia : the Official Journal of the World Federation of Hemophilia·S HayaUNKNOWN Spanish Immune Tolerance Group
Jan 6, 1994·The New England Journal of Medicine·L W Hoyer
Jul 20, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·C S GrahamM J Koziel
Jul 1, 1995·British Journal of Haematology·L W Hoyer
Jan 1, 1995·Haemophilia : the Official Journal of the World Federation of Hemophilia·W KreuzB Kornhuber
Oct 1, 1995·Haemophilia : the Official Journal of the World Federation of Hemophilia·S AronisA Mitsika
Jan 1, 1996·Vox Sanguinis·W KreuzB Kornhuber
Jun 20, 1992·Lancet·R LjungI M Nilsson
Jun 29, 2004·Journal of Thrombosis and Haemostasis : JTH·S C DarbyUNKNOWN UK Haemophilia Centre Doctors' Organisation
Jun 29, 2004·Journal of Thrombosis and Haemostasis : JTH·D Dimichele
May 14, 2004·Journal of Thrombosis and Haemostasis : JTH·L M Aledort
Jun 28, 2003·Haemophilia : the Official Journal of the World Federation of Hemophilia·J Wight, S Paisley
May 13, 2009·Haemophilia : the Official Journal of the World Federation of Hemophilia·J G van der BomN S Weiss
Nov 25, 2006·Haemophilia : the Official Journal of the World Federation of Hemophilia·Charles R M Hay
Sep 28, 2006·Journal of Thrombosis and Haemostasis : JTH·C L KemptonT C Abshire
Mar 4, 2008·Haemophilia : the Official Journal of the World Federation of Hemophilia·A Mäkipernaa, L von Bonsdorff
Oct 23, 2009·Haemophilia : the Official Journal of the World Federation of Hemophilia·J S StonebrakerM Brooker
Apr 29, 2015·Journal of Thrombosis and Haemostasis : JTH·C L EckhardtUNKNOWN INSIGHT Study Group
Jan 24, 2015·American Journal of Hematology·Christopher E WalshUNKNOWN United States Hemophilia Treatment Center Network
Jun 25, 2016·Haemophilia : the Official Journal of the World Federation of Hemophilia·K VepsäläinenP Riikonen
Nov 1, 1994·American Journal of Hematology·L Aledort
Nov 16, 2018·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Sayed H MousaviSirous Zeinali

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.