Haemophilus influenzae induced loss of lung beta-adrenoceptor binding sites and modulation by changes in peripheral catecholaminergic input

European Journal of Pharmacology
A J Schreurs, F P Nijkamp

Abstract

Vaccination of guinea pigs with killed suspensions of Haemophilus influenzae, a bacterium often found in the deeper respiratory airways of asthmatic bronchitics, results in a number of effects suggesting an impairment of beta-adrenoceptor function. A [3H]dihydroalprenolol binding assay was used to determine the number of beta-adrenoceptors (Bmax) following H. influenzae vaccination. The Bmax declined significantly by 29% from 1240 +/- 80 to 880 +/- 70 fmol/mg protein, while the binding affinity of the sites was not changed. Specific binding in the presence of 1.8 nM [3H]DHA to tracheal longitudinal smooth muscle was also significantly lower in H. influenzae-vaccinated animals as compared to controls. Furthermore modulation of peripheral sympathetic input to lung beta-adrenoceptors was evaluated in our model. Pretreatment with Ro4-4602, an inhibitor of dopa-decarboxylase, increased the number of beta-adrenoceptors and prevented the H. influenzae-induced loss of beta-adrenoceptors. On the other hand repeated doses of the antidepressant desipramine mimicked the effect of H. influenzae vaccination i.e. a loss of beta-adrenoceptors. Desipramine and H. influenzae vaccination were not synergistic in their effects. The effects of H. in...Continue Reading

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Citations

Sep 1, 1982·Naunyn-Schmiedeberg's Archives of Pharmacology·A J SchreursF P Nijkamp
Aug 17, 1989·Klinische Wochenschrift·A SchusterD Reinhardt
Oct 1, 1984·Agents and Actions·A J Schreurs, F P Nijkamp
Feb 1, 1984·Veterinary Research Communications·A J Schreurs, F P Nijkamp
Jan 28, 1983·European Journal of Pharmacology·A J SchreursF P Nijkamp
Jan 28, 1983·European Journal of Pharmacology·A J TurnerJ Shaw
Dec 10, 1985·European Journal of Pharmacology·G Folkerts, F P Nijkamp
Jan 1, 1987·International Journal of Immunopharmacology·P A HenricksF P Nijkamp
Apr 22, 1983·European Journal of Pharmacology·M P AbbracchioC Omini
Nov 1, 1988·Prostaglandins, Leukotrienes, and Essential Fatty Acids·C LoesbergF P Nijkamp
Jan 1, 1987·Annals of the New York Academy of Sciences·A J Van Oosterhout, F P Nijkamp
Jul 1, 1986·Acta Oto-laryngologica·P LotzA Ernst
Apr 1, 1988·European Journal of Clinical Investigation·M GrieseD Reinhardt

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