Haemophilus influenzae Serotype a (Hia) Carriage in a Small Alaska Community After a Cluster of Invasive Hia Disease, 2018.

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Leisha D NolenMichael G Bruce

Abstract

Between May and July 2018, 4 Haemophilus influenzae serotype a (Hia) infections occurred in a remote Alaska community. We performed a public health response to prevent further illness and understand Hia carriage. We collected oropharyngeal samples community-wide to evaluate baseline carriage. Risk factors were evaluated by interview. We offered prophylactic rifampin to individuals in contact with invasive Hia patients (contacts) and to all children aged <10 years. Oropharyngeal samples were collected again 8 weeks after rifampin distribution. Samples were tested using real-time polymerase chain reaction and culture. At baseline, 4 of 27 (14.8%) contacts and 7 of 364 (1.9%) noncontacts (P < .01) carried Hia. Contacts aged <10 years were more likely to carry Hia at any timepoint (11/18 [61%]) compared to contacts aged ≥10 years (3/34 [8.8%]), noncontacts aged <10 years (2/139 [1.4%]), and noncontacts ≥10 years (6/276 [2.2%]) (P < .001 for all). Hia carriers were clustered in 9 households (7% of total households). At the household level, carriage was associated with households with ≥1 contact (prevalence ratio [PR], 5.6 [95% confidence interval {CI}, 1.3-21.6]), crowding (PR, 7.7 [95% CI, 1.1-199.5]), and ≥3 tobacco users (PR, 5.0...Continue Reading

References

Aug 1, 1987·The Pediatric Infectious Disease Journal·C V Broome
Jan 1, 1995·The Journal of Infectious Diseases·M L BarbourE R Moxon
Mar 1, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Eugene V MillarMathuram Santosham
May 7, 2005·The Pediatric Infectious Disease Journal·Laura L HammittJay C Butler
Apr 7, 2006·Journal of Clinical Microbiology·Raymond S W TsangDennis K S Law
Jun 29, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Laura L HammittJay C Butler
May 23, 2009·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Marina Ulanova, Raymond S W Tsang
Mar 31, 1931·The Journal of Experimental Medicine·M Pittman
Feb 25, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jeffrey M BenderAndrew T Pavia
Jun 6, 2013·Emerging Infectious Diseases·Michael G BruceJay D Wenger
Nov 26, 2013·The Lancet Infectious Diseases·Marina Ulanova, Raymond S W Tsang
Jan 9, 2016·The Canadian Journal of Infectious Diseases & Medical Microbiology = Journal Canadien Des Maladies Infectieuses Et De La Microbiologie Médicale·Andrée-Anne Boisvert, Dorothy Moore
Feb 23, 2017·Memórias do Instituto Oswaldo Cruz·Mari TuyamaDavid E Barroso
May 5, 2017·The Pediatric Infectious Disease Journal·María Del Mar Ortiz-RomeroUNKNOWN Collaborators of Study Group of Infectious Diseases in the Child in Cartagena
Dec 5, 2017·The Pediatric Infectious Disease Journal·Joanne McNairUNKNOWN Canadian Immunization Monitoring Program Active (IMPACT) Investigators
Mar 7, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Heidi M SoetersElizabeth C Briere
May 21, 2019·The Pediatric Infectious Disease Journal·Jesus G VallejoSheldon L Kaplan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

International Journal of Health Policy and Management
Ali FakhriPatrick J Harris
International Journal of Environmental Research and Public Health
Mirko S WinklerAstrid M Knoblauch
© 2022 Meta ULC. All rights reserved