PMID: 6966956Mar 29, 1980Paper

Haemophilus influenzae type B meningitis: a contagious disease of children

British Medical Journal
M P GlodeA Smith

Abstract

The families of 126 consecutive patients with Haemophilus influenzae type B meningitis were surveyed for secondary invasive H influenzae disease among household contacts. A total of 120 of the families were contacted. In six cases no contact was possible and the medical record was reviewed. Some 555 household contacts were found; 31% (171) were under 5 years of age. A secondary case was defined as a household contact with H influenzae type B isolated from blood or cerebrospinal fluid more than 24 hours, but less than 30 days, after admission to hospital of the index case. Four secondary cases were identified, all in children aged under 5 years. The secondary attack rate in children under 5 years or less in the month after exposure to an index case was thus 2.3%, 800 times the endemic attack rate for H influenzae meningitis. This is a conservative estimate since five additional contact cases were documented, but not included in the secondary attack rate. Young contacts of a child with H influenzae meningitis are thus at significant risk of life-threatening secondary disease.

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Citations

Aug 1, 1987·The Journal of Pediatrics·S MakintubeeJ I Ward
Jun 30, 1984·Lancet·G W Hanks, R G Twycross
Jun 30, 1984·Lancet·P C Chan, P J Sanderson
Mar 1, 1982·Antimicrobial Agents and Chemotherapy·L E NicolleA R Ronald
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Jan 1, 1986·Archives of Disease in Childhood·H Smith
Jul 7, 1984·British Medical Journal·A J Davies, D A Lewis
Oct 13, 1984·British Medical Journal·R G Finch
Mar 9, 1991·BMJ : British Medical Journal·K A CartwrightD Hull
Feb 24, 2016·Journal of Immunology Research·Adi Essam ZareiElrashdy M Redwan
Jan 21, 2009·The Journal of Infection·Shamez LadhaniMary E Ramsay
Feb 3, 2005·Biological Reviews of the Cambridge Philosophical Society·Bruno A Walther, Paul W Ewald
Aug 1, 1987·The Journal of Pediatrics·M I Marks, W L Dorchester
Nov 1, 1989·The Journal of Pediatrics·A K TakalaP H Mäkelä
Jul 1, 1984·The Journal of Infection·S J Broughton, R E Warren
May 1, 1987·The Journal of Infection·J EskolaP H Mäkelä
Oct 1, 1982·Clinical Pediatrics·S D HandlerJ J Downes
Mar 10, 1984·British Medical Journal·H P Lambert
Dec 1, 1987·Australian Paediatric Journal·G L Gilbert
Aug 1, 1994·Journal of Paediatrics and Child Health·T Lipson
Nov 12, 2014·The Pediatric Infectious Disease Journal·Edwin J Asturias
Jun 1, 1982·The Journal of Hygiene·P G DaveyA M Geddes

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