PMID: 9427456Jan 14, 1998Paper

Haemophilus influenzae type b-specific antibody in infants after maternal immunization

The Pediatric Infectious Disease Journal
Janet A EnglundG R Siber

Abstract

To study the kinetics of Haemophilus influenzae type b (Hib)-specific antibody in infants born to mothers immunized with an Hib polysaccharide or one of two Hib conjugate vaccines. Serum antibody to the polyribosylribitol (PRP) moiety of Hib was measured by radioimmunoassay and enzyme-linked immunosorbent assay at birth and at 2 and 6 months of age in infants born to women immunized with Hib polysaccharide or conjugate vaccine (PRP-D and HbOC). A subset of infants > or = 6 months of age was immunized with Hib conjugate vaccine after licensure of this vaccine for infants. A comparison group of 18 infants born to unimmunized women received the same Hib conjugate vaccine on a similar schedule. Total PRP antibody concentrations were 1.50, 14.4 and 20.4 microg/ml in 2-month-old infants born to mothers immunized with polysaccharide, PRP-D and HbOC vaccines, respectively, and 2.54, 1.35 and 2.46 microg/ml in 6-month-old infants. Infants born to mothers immunized with polysaccharide vaccine had significantly less PRP antibody at 2 months of age but similar antibody concentrations at 6 months of age. Persistence or increases in total PRP antibody during 6 months were noted in 21 of 47 (44.6%) study infants. A subset of study and compari...Continue Reading

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Citations

Mar 11, 2004·Archives of Medical Research·Wilma Basualdo, Antonio Arbo
Dec 12, 2001·Primary Care·W P Glezen
Nov 26, 2009·The Pediatric Infectious Disease Journal·Janet A EnglundUNKNOWN GRC28 Study Team
Jun 10, 1998·American Journal of Public Health·W P Glezen
Jan 12, 2012·Clinical & Developmental Immunology·Patricia PalmeiraMagda Carneiro-Sampaio
May 7, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Helen Y Chu, Janet A Englund
Mar 1, 2007·Women's Health·Flor M Munoz
Dec 3, 2010·Early Human Development·J P van den BergR M van Elburg
Jun 15, 2007·Journal of Comparative Pathology·E Vidor
Apr 17, 2001·Infectious Disease Clinics of North America·F M Munoz, J A Englund
Dec 11, 2003·Revista do Hospital das Clínicas·Lucia Ferro Bricks
Apr 13, 2000·Pediatric Clinics of North America·F M Munoz, J A Englund
Apr 29, 2006·Current Opinion in Infectious Diseases·C Mary Healy, Carol J Baker
Apr 12, 2017·Birth Defects Research·Helen Y Chu, Janet A Englund
Jan 5, 1999·Clinical and Diagnostic Laboratory Immunology·B T CarvalhoR U Sorensen
Oct 12, 2021·Journal of Medical Virology·Nusrat HomairaAdam Jaffe
Nov 15, 2021·American Journal of Obstetrics and Gynecology·Melanie EttiPaul T Heath

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