Haemophilus influenzae type b vaccine: reconstitution of lyophilised PRP-T vaccine with a pertussis-containing paediatric combination vaccine, or a change in the primary series immunisation schedule, may modify the serum anti-PRP antibody responses

Current Medical Research and Opinion
E VidorM A Fletcher

Abstract

Immunogenicity data obtained after primary series immunisations against Haemophilus influenzae type b (Hib), using a vaccine prepared by conjugating the capsular polysaccharide of Hib to tetanus toxoid (ActHIB), were compiled from 146 study groups comprising 85 clinical trials or vaccination programs conducted between 1987 and 1999. ActHIB was administered as a monovalent lyophilised vaccine, injected either in association with another paediatric vaccine (at separate administration sites) or in combination (where the different vaccines are mixed together in the same syringe before injection). Review of these data reveals two trends. First, PRP-T vaccine, given either alone or in combination with DTwcP, resulted in a stronger anti-PRP serum antibody response than when PRP-T was combined with DTacP vaccine. Second, an accelerated (i.e. one-month interval) immunisation schedule tended to induce a poorer anti-PRP antibody response than did the more widely spaced, standard inoculation schedules. Although an in-depth analysis of these over 11000 study subjects on an individual basis with multivariate analysis or multifactorial statistical methods might eventually provide working hypotheses to fully understand these phenomenon, the va...Continue Reading

Citations

May 5, 2006·Journal of Clinical Microbiology·Belén AracilJosé Campos
May 31, 2003·BMJ : British Medical Journal·Paul T Heath, Mary E Ramsay
Oct 1, 2008·Clinical & Developmental Immunology·Peter Klein Klouwenberg, Louis Bont
Apr 14, 2006·Expert Opinion on Drug Safety·Naor Bar-Zeev, Jim P Buttery
Jun 15, 2007·Journal of Comparative Pathology·E Vidor
Nov 29, 2011·Vaccine·Anne von GottbergUNKNOWN Group for Enteric, Respiratory, Meningeal Disease Surveillance in South Africa (GERMS-SA)

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