PMID: 6105516Aug 23, 1980Paper

Haemopoietic recovery in Ewing's sarcoma after intensive combination therapy and autologous marrow infusion

Lancet
R A AbramsA B Deisseroth

Abstract

After the completion of combination therapy designed to achieve local control of Ewing's sarcoma, 13 patients with either truncal primary lesions or proven metastases were given 150 rad of total body irradiation over 5 weeks followed by cyclophosphamide, doxorubicin, imidazole carboxamide, and vincristine. 11 patients received autologous cryopreserved marrow infusions. In 2 patients marrow collections were not attempted. Two patterns of haemopoietic recovery were observed: 8 patients, who had received marrow infusions, showed leucocyte, granulocyte, and platelet recovery by 27, 28, and 30 days. 5 patients, 3 of whom had also received marrow, showed more delayed recovery with leucocyt, granulocyte, and platelet recovery at 45, 53, and 77+ days. Delayed recovery in patients receiving marrow seemed to correlate with aberrations in marrow freezing-rate during phase change, and these aberrations could be shown to diminish post-freeze recovery of marrow granulocyte-monocyte precursor cells.

References

Jan 1, 1976·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J S Tobias, M H Tattersall
Oct 1, 1970·Blood·E D Thomas, R Storb

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Citations

Jan 1, 1982·Breast Cancer Research and Treatment·P S Stewart
Dec 1, 1983·International Journal of Radiation Oncology, Biology, Physics·T J KinsellaE Glatstein
Feb 22, 2002·Critical Reviews in Oncology/hematology·S Burdach, H Jürgens
May 1, 1981·The Journal of Clinical Investigation·R A AbramsA B Deisseroth
Jun 1, 1983·Pediatric Annals·C Lenarsky, S A Feig
Oct 18, 2016·British Journal of Haematology·Michael J Watts, David C Linch
Jun 15, 1981·International Journal of Cancer. Journal International Du Cancer·G L Floersheim, J Torhorst
Jan 1, 1992·Journal of Clinical Apheresis·S T BennettL C Lasky
Feb 1, 1986·Clinics in Haematology·N C Gorin

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