Abstract
To evaluate the influence of haemorheopheresis on anatomical and functional findings in patients with soft-drusen maculopathy. We investigated 29 eyes (16 patients) and randomized 25 eyes (16 controls) with soft-drusen maculopathy [soft, confluent and reticular drusen, drusenoid retinal pigment epithelium detachment (RPED)]. Each patient received a series of eight haemorheophereses (cascade filtration of 1.5 plasma volume) within 10 weeks. The patients were followed up using Early Treatment Diabetic Retinopathy Study (ETDRS) charts, optical coherence tomography, fluorescein angiography, electroretinography and measurements of pulsed ocular blood flow. After the procedures, there was a substantial reduction in rheologically active substances [lipoproteins, α2-macroglobulin, immunoglobulin M (IgM), fibrinogen], plasma and blood viscosity. At the 1.5-year follow-up, we noticed soft drusen absorption; reattachment of drusenoid RPED and stabilization or improvement of visual acuity occurred in 72% of patients in comparison to only 39% of patients in the control group. Full-field electroretinograms showed significantly higher scotopic activity of treated patients in comparison with the control group, and mainly insignificant differen...Continue Reading
References
Oct 20, 2000·Retina·R BrunnerH Borberg
Dec 9, 2000·Therapeutic Apheresis : Official Journal of the International Society for Apheresis and the Japanese Society for Apheresis·R KlingelJ Berrouschot
Aug 8, 2002·Therapeutic Apheresis : Official Journal of the International Society for Apheresis and the Japanese Society for Apheresis·Reinhard KlingelFrank Koch
Jul 25, 2003·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Reinhard KlingelBritta Göhlen
Oct 1, 2004·Documenta Ophthalmologica. Advances in Ophthalmology·Michael F MarmorUNKNOWN International Society for Clinical Electrophysiology of Vision
Nov 4, 2004·The International Journal of Artificial Organs·M ValbonesiP Carlier
Apr 9, 2005·Journal of Microscopy·J C Fiala
Dec 14, 2005·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Helmut Borberg, Michael Tauchert
Mar 11, 2006·American Journal of Ophthalmology·Mauricio FigueroaJuan E Grunwald
Apr 4, 2006·Ophthalmology·Thomas R FribergUNKNOWN PTAMD Study Group
Jun 24, 2006·Current Opinion in Ophthalmology·Mark J Donaldson, Jose S Pulido
Sep 9, 2006·Trials·Patricio López-JaramilloGustavo A Márquez
Nov 23, 2006·Urology·Gerald HokeWalter Rayford
Feb 3, 2007·Ophthalmology·Ronald KleinRonald E Gangnon
Jun 20, 2007·The British Journal of Ophthalmology·Itay Ben ZionHanna J Garzozi
Nov 1, 2007·Documenta Ophthalmologica. Advances in Ophthalmology·Donald C HoodAnja M Palmowski-Wolfe
Nov 10, 2007·The International Journal of Artificial Organs·M FerranniniN Di Daniele
Nov 30, 2007·American Journal of Ophthalmology·Ronald KleinBarbara E K Klein
Citations
Jan 1, 2013·BioMed Research International·Milan KošťálHana Langrová
Jan 30, 2013·Atherosclerosis. Supplements·M BlahaL Sobotka
Sep 14, 2012·Acta Ophthalmologica·Eva RencováHana Langrová
Feb 2, 2013·Journal of Clinical Apheresis·Jeffrey L Winters
Sep 10, 2015·Journal of Ophthalmology·Eva RencováHana Langrová
May 6, 2015·Atherosclerosis. Supplements·M BlahaP Zak
Jan 24, 2014·Journal of Ophthalmology·Jan StudničkaHana Langrová
Nov 19, 2017·Journal of Clinical Apheresis·Brendan C GrahamJeffrey L Winters
Mar 26, 2016·The Open Ophthalmology Journal·Sukjin KimKiseok Kim
Jun 11, 2019·Journal of Clinical Apheresis·Anand PadmanabhanGuest Editor Joseph Schwartz
Aug 27, 2013·Expert Review of Clinical Pharmacology·Ella Leung, Gennady Landa
May 26, 2018·Medicine·Yanli WeiJian Ye
Aug 28, 2015·Vestnik oftalmologii·V R MamikonyanT A Kakunina
Jul 18, 2020·Clinical Hemorheology and Microcirculation·M BlahaM Kostal