Haemorheopheresis could block the progression of the dry form of age-related macular degeneration with soft drusen to the neovascular form

Acta Ophthalmologica
Eva RencováHana Langrová

Abstract

To evaluate the influence of haemorheopheresis on anatomical and functional findings in patients with soft-drusen maculopathy. We investigated 29 eyes (16 patients) and randomized 25 eyes (16 controls) with soft-drusen maculopathy [soft, confluent and reticular drusen, drusenoid retinal pigment epithelium detachment (RPED)]. Each patient received a series of eight haemorheophereses (cascade filtration of 1.5 plasma volume) within 10 weeks. The patients were followed up using Early Treatment Diabetic Retinopathy Study (ETDRS) charts, optical coherence tomography, fluorescein angiography, electroretinography and measurements of pulsed ocular blood flow. After the procedures, there was a substantial reduction in rheologically active substances [lipoproteins, α2-macroglobulin, immunoglobulin M (IgM), fibrinogen], plasma and blood viscosity. At the 1.5-year follow-up, we noticed soft drusen absorption; reattachment of drusenoid RPED and stabilization or improvement of visual acuity occurred in 72% of patients in comparison to only 39% of patients in the control group. Full-field electroretinograms showed significantly higher scotopic activity of treated patients in comparison with the control group, and mainly insignificant differen...Continue Reading

Associated Clinical Trials

References

Dec 9, 2000·Therapeutic Apheresis : Official Journal of the International Society for Apheresis and the Japanese Society for Apheresis·R KlingelJ Berrouschot
Aug 8, 2002·Therapeutic Apheresis : Official Journal of the International Society for Apheresis and the Japanese Society for Apheresis·Reinhard KlingelFrank Koch
Jul 25, 2003·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Reinhard KlingelBritta Göhlen
Oct 1, 2004·Documenta Ophthalmologica. Advances in Ophthalmology·Michael F MarmorUNKNOWN International Society for Clinical Electrophysiology of Vision
Nov 4, 2004·The International Journal of Artificial Organs·M ValbonesiP Carlier
Apr 9, 2005·Journal of Microscopy·J C Fiala
Dec 14, 2005·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Helmut Borberg, Michael Tauchert
Mar 11, 2006·American Journal of Ophthalmology·Mauricio FigueroaJuan E Grunwald
Jun 24, 2006·Current Opinion in Ophthalmology·Mark J Donaldson, Jose S Pulido
Jun 20, 2007·The British Journal of Ophthalmology·Itay Ben ZionHanna J Garzozi
Nov 1, 2007·Documenta Ophthalmologica. Advances in Ophthalmology·Donald C HoodAnja M Palmowski-Wolfe
Nov 10, 2007·The International Journal of Artificial Organs·M FerranniniN Di Daniele
Nov 30, 2007·American Journal of Ophthalmology·Ronald KleinBarbara E K Klein

❮ Previous
Next ❯

Citations

Jan 30, 2013·Atherosclerosis. Supplements·M BlahaL Sobotka
Feb 2, 2013·Journal of Clinical Apheresis·Jeffrey L Winters
Nov 19, 2017·Journal of Clinical Apheresis·Brendan C GrahamJeffrey L Winters
Aug 27, 2013·Expert Review of Clinical Pharmacology·Ella Leung, Gennady Landa
Aug 28, 2015·Vestnik oftalmologii·V R MamikonyanT A Kakunina

❮ Previous
Next ❯

Related Concepts

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Related Papers

American Journal of Ophthalmology
Ronald KleinBarbara E K Klein
Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy
Milan BláhaVít Rehácek
Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde
Zhang Ni, Peng Hui
© 2021 Meta ULC. All rights reserved