Haemorrhagic complications in paediatric dialysis-dependent acute kidney injury: Incidence and impact on outcome

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Martin KreuzerLars Pape

Abstract

The occurrence of haemorrhagic complications in children with dialysis-dependent acute kidney injury (dAKI) and its contribution to morbidity and mortality is unclear. The objective of this retrospective analysis was to investigate the dialysis modalities, haemorrhagic complications and outcome of dAKI in children and adolescents. Data from 198 children and adolescents (median age 3 years, range 0-18 years) with dAKI from 2000 to 2006 was analysed for bleeding risks, haemorrhagic complications, underlying diseases, associated variables and mortality. One hundred and seven patients underwent peritoneal dialysis (PD), 71 continuous haemofiltration (CVVH) and 20 intermittent haemodialysis (HD) using systemic heparinization. Fifty-three of 198 children (27%) suffered from one or more haemorrhagic complications; 63% of these complications were life-threatening. Bleeding was mainly diffuse (35 of 53). The incidence of haemorrhagic complications was significantly higher in patients on HD or CVVH compared to those on PD. Regression analysis of data showed that previous bleeding episodes or surgery, the underlying disease and the presence of multi-organ dysfunction syndrome (MODS) were strongly associated with haemorrhagic complications...Continue Reading

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Citations

May 15, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Martin KreuzerLars Pape
Oct 22, 2010·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Martin KreuzerLars Pape
Aug 1, 2015·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Martin KreuzerLars Pape
Jul 8, 2015·Journal of Thrombosis and Haemostasis : JTH·L Raffini, C Witmer
Apr 21, 2012·Hemodialysis International·Ljubica DjukanovićAnica Cvetičanin

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