PMID: 7336960Jul 1, 1981Paper

Haemorrhagic toxicosis in rats given butylated hydroxytoluene

Acta Pharmacologica Et Toxicologica
O Takahashi, K Hiraga

Abstract

Vascular permeability, platelet function, blood coagulation and fibrinolytic activity were examined in Sprague-Dawley male rats given 1.20% butylated hydroxytoluene (BHT) in the diet for 1 week. BHT significantly increased the leakage of Evans blue from blood into epididymus. BHT inhibited the ADP-induced platelet aggregation and decreased the platelet factor 3 availability. Plasma prothrombin, factors IX, X, VII and VIII were decreased in rats given BHT. Fibrinolytic activity was little influenced by BHT-feeding.

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Citations

Feb 2, 2000·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·K WaltonB Schilter
Mar 16, 2000·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·O Takahashi
Oct 1, 1985·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·O Takahashi
Aug 15, 1984·Biochemical Pharmacology·Y NakagawaK Hiraga
Mar 1, 1987·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·O Takahashi
Feb 1, 1984·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·O Takahashi, K Hiraga
Aug 1, 1990·Toxicology·O TakahashiM Sasaki

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