Abstract
Post mortem liver samples from 12 donkeys (Equus asinus) aged 21-57 years (4 females, 1 stallion, 7 geldings), were assessed chemically for copper and iron content on a wet weight basis and histologically for stainable iron. Chemical liver copper content ranged from 2.7 to 4.8μg/g (mean 3.5±0.05μg/g). Chemical liver iron content ranged from 524 to 5010μg/g (mean 1723±1258μg/g). Histochemical iron was measured morphometrically using a computer-based image analysis system; percentage section area staining for iron ranged from 0.84% to 26.69% (mean 10.82±8.36%). There was no clear correlation, within the wide range of iron values, between histochemically demonstrable iron and chemically measured iron content. No clear age-related increase was apparent for either parameter in these aged donkeys. The accumulation of iron in the liver of donkeys may represent a physiological haemosiderosis rather than pathological haemochromatosis.
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Oct 20, 2012·Journal of Comparative Pathology·R Klopfleisch, P Olias
Jul 27, 2010·Research in Veterinary Science·P J BrownF A Burden
Apr 5, 2014·Chemosphere·Sawako HoraiShinsuke Tanabe
Feb 19, 2013·Toxicologic Pathology·A Peter HallAlison Bigley