Haemostasis and prevention of bleeding related to ER: The role of a novel self-assembling peptide

United European Gastroenterology Journal
Sharmila SubramaniamPradeep Bhandari

Abstract

Endoscopic resection is now commonly used for removal of early gastrointestinal lesions. However, the risk of the procedure may be heightened by intraprocedural or delayed bleeding. A novel, self-assembling peptide (PuraStat®) was recently licensed for use as a haemostat. The aim of this study was to assess the efficacy and safety of this haemostat when used to control intraprocedural bleeding or to prevent delayed bleeding in endoscopic resection. PuraStat® was used on 100 patients undergoing endoscopic resection in a tertiary referral centre. The efficacy, safety, feasibility of use and delayed bleeding rates were measured. Forty-eight oesophageal, 31 colorectal, 11 gastric and 10 duodenal procedures were included. The mean lesion size was 3.7 cm and 30% of the patients were on antithrombotic therapy. Intraprocedural bleeding occurred in 64%. PuraStat® was an effective haemostat in 75% of these cases. Only a small amount was required for haemostasis (mean = 1.76 ml) and it took on average 69.5 seconds to stop a bleed. The delayed bleeding rate was 3%. PuraStat® is an effective haemostat for use in controlling bleeds during endoscopic resection. It is safe, easy to use and did not interfere with the procedure.

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Citations

Dec 6, 2019·The Laryngoscope·Masayoshi YoshimatsuKoichi Omori
Sep 5, 2020·Molecular Genetics & Genomic Medicine·Carmen Martínez ValenzuelaAna Laura Calderón-Garcidueñas
Jun 16, 2021·Surgical Endoscopy·Federica BranchiChristian Bojarski
Jun 15, 2021·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Antonio FacciorussoRodolfo Sacco
Jun 25, 2021·Frontiers in Bioengineering and Biotechnology·Sharanya SankarLisa Spirio

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Methods Mentioned

BETA
dissection
surgical resection

Software Mentioned

PuraStat®
EndoClot

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