Haemostasis disorders caused by snake venoms

Annales Françaises D'anesthèsie Et De Rèanimation
S LarréchéM Goyffon

Abstract

Various haemostasis disorders can occur following snakebite. Almost all ophidian species that are responsible for serious, even lethal, human envenomations are concerned. Venoms of these snakes are rich in proteins interfering with haemostasis, including many enzymes. These proteins can be classified in four groups according to their action. The haemorrhagins induce capillary permeability disorders. The proteins disturbing the primary haemostasis can activate as well as inhibit platelets: phospholipases A2, serine proteases and metalloproteinases, L-amino-acido-oxydases, phosphoesterases, disintegrins, C-type lectins, dendropeptin, agregoserpentin, thrombolectin. The proteins interfering with coagulation are separated into procoagulant proteases (prothrombin activator, thrombin-like enzymes, factor X and factor V activators) and anticoagulant proteases (factor IX and X inhibitors, protein C activator, anticoagulant phospholipases A2). The venom components acting on fibrinolysis are the fibrinolytic enzymes and the plasminogene activators. The clinical consequence of these mechanisms is a local as well as diffuse haemorrhagic syndrome. A hypofibrinogenemy, even an afibrinogenemy is frequently noted. Other haemostasis parameters ...Continue Reading

References

Oct 31, 2002·Intensive Care Medicine·Mario Von Depka
Jun 1, 2005·Toxicon : Official Journal of the International Society on Toxinology·Julian White
Jun 1, 2005·Toxicon : Official Journal of the International Society on Toxinology·Neville Marsh, Vaughan Williams
Aug 17, 2005·Journal of Thrombosis and Haemostasis : JTH·Q LuK J Clemetson
Oct 18, 2005·The Medical Clinics of North America·Eunice M SingletaryChristopher P Holstege

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Citations

Jul 25, 2009·Journal of Thrombosis and Thrombolysis·M S KumarK Kemparaju
Jun 30, 2012·Bulletin de la Société de pathologie exotique·M ChaniG Mion
Dec 3, 2014·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·H ChabliS Younous
Dec 14, 2011·Annales Françaises D'anesthèsie Et De Rèanimation·M ChaniG Mion
Dec 15, 2010·Annales Françaises D'anesthèsie Et De Rèanimation·A El KoraichiS Ech-Chérif El Kettani
Aug 4, 2009·Annales Françaises D'anesthèsie Et De Rèanimation·Y MahjoubH Dupont
Apr 15, 2008·Annales Françaises D'anesthèsie Et De Rèanimation·B Debien, G Mion
Apr 22, 2008·Annales Françaises D'anesthèsie Et De Rèanimation·M ChaniG Mion
Oct 5, 2010·Proteomics·Roberto GuerrantiRoberto Leoncini
Jan 26, 2018·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Sébastien LarréchéChristophe Martinaud
Jul 2, 2020·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Xavier HeckmannSébastien Larréché
Jul 3, 2020·Frontiers in Pharmacology·Pengpeng LiMingqiang Rong
Oct 15, 2020·Biochemistry. Biokhimii︠a︡·S K M NandishD Sannaningaiah
Feb 1, 2011·Toxicon : Official Journal of the International Society on Toxinology·Tamara SajevicIgor Križaj

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