Abstract
We have evaluated the link between haemostatic abnormalities and immune dysfunction in liver disease by evaluating parameters of cellular and humoral immunity in conjunction with coagulation profiles in rats following portacaval anastomosis, induction of portal hypertension by portal vein stenosis or by sham surgical procedures. Twelve weeks following surgery, portacaval shunted rats were markedly anaemic (8.9 +/- 0.6 g/dl; controls 12.3 +/- 1.4 g/dl, p < 0.05), had low plasma fibrinogen levels (0.6 +/- 0.3 g/l, controls 2.5 +/- 0.2 g/l p < 0.05) and markedly elevated fibrin(ogen) degradation products (FDP) titres (1/40-1/80; controls < 1/10. p < 0.05). Portal vein stenosed rats were less anaemic (11.5 +/- 0.8 g/dl), had near normal fibrinogen levels (2.1 +/- 0.3 g/l) but elevated FDP levels (1/40-1/80). Both portacaval shunted and portal vein stenosed rats had elevated serum IgG levels (35.1 +/- 14.1 g/l; 29.2 +/- 13.9 g/l respectively; control values 20 +/- 5.9 g/l p < 0.05 for comparison with both experimental groups). Intrinsic lymphocyte proliferation to T and B cell mitogens was markedly depressed in the portacaval anastamosed rats when compared to controls. Serum factors inhibitory to control lymphocyte proliferation wer...Continue Reading
References
Jan 1, 1976·Methods in Cell Biology·P O Seglen
Oct 1, 1979·Digestive Diseases and Sciences·J D Stobo
Oct 1, 1978·Gut·D R TrigerJ Levin
Feb 5, 1976·Nature·G GirmannP G Scheurlen
Feb 1, 1992·Liver·Y ItohK Kashima
Feb 1, 1991·Gut·C BabbsF W Ballardie
Mar 1, 1991·Journal of Hepatology·D R Triger
Jul 1, 1990·Journal of Gastroenterology and Hepatology·S K SarinS L Broor
Oct 1, 1989·The Journal of Experimental Medicine·S D WrightR A Ramos
May 4, 1989·The New England Journal of Medicine·A F SuffrediniJ E Parrillo
Jul 1, 1989·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J M Carr
Nov 1, 1989·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J P Nolan
Mar 1, 1985·Clinical Science·I A Rajkovic, R Williams
Apr 1, 1988·Gastroenterology·D VallaJ P Benhamou
Sep 1, 1988·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S A CummingsR J Groszmann
Jun 30, 1973·Lancet·D R Triger, R Wright
Apr 1, 1972·The Journal of Clinical Investigation·C MerskeyP Lalezari
Jun 1, 1983·The Journal of Clinical Investigation·M ColucciN Semeraro
Jan 1, 1984·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A RimolaJ Rodes
Oct 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S C RobsonR E Kirsch
Apr 1, 1957·Acta Haematologica·A CLAUSS