Dec 1, 1977

Haemostatic disorders and respiratory distress in the newborn

Intensive Care Medicine
C BoyerH Mathieu

Abstract

Coagulation and fibrinolysis studies were performed on 64 newborns; 16 premature infants with hyaline membrane disease (HMD), 17 newborns with other forms of respiratory distress syndrome (RDS) (8 of them were premature), 31 healthy newborns (11 of them were premature). All the babies were studied once in the first 48 hours of life. There was no significant difference between sick and healthy babies for 5 parameters; platelet count, factor VIII, fibrinogen, fibrin(ogen) degradation products, euglobulin lysis time. Factor II, VII and X were low in all infants, and premature infants had significantly lower levels compared to full term newborns. Factor V, plasminogen, alpha 2 macroglobulin (alpha 2M) and antithrombin III (AT III) levels were significantly lower in sick infants. Except for AT III, these deficiencies were not related to prematurity. No significant difference was found between HMD and other RDS. Of the 33 sick infants, 5 developed laboratory findings consistent with disseminated intravascular coagulation (DIC). The results indicate that the coagulation and fibrinolytic abnormalities reported are not specific to HMD.

  • References20
  • Citations2

References

Mentioned in this Paper

Antithrombin III, Human
Fibrin Measurement
Alpha 1-Acute Phase Globulin
Disseminated Intravascular Coagulation
Clotting Factor II Assay
Fibrinogen
Fibrinogen Assay
Plasminogen Measurement
Factor V
F2 gene

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