Haemostatic factors, atherosclerosis and risk of abdominal aortic aneurysm

Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis
A J LeeA Rumley

Abstract

Abdominal aortic aneurysms have traditionally been thought to be a consequence of severe atherosclerosis of the arterial wall. To date, the role of haemostatic factors in aneurysmal disease has not been extensively researched. The aim of this study was to see if such factors were independently related to the occurrence of aortic aneurysm. Furthermore, were the associations maintained after taking into account the presence of underlying atherosclerotic disease? Using data from the Edinburgh Artery Study, a nested case-control design was used involving 40 cases of aortic aneurysm, each being matched to five controls by sex and within a 5-year age band. After adjustment for age and sex, both fibrinogen (P < or = 0.01) and fibrin D-dimer (P < or = 0.001) were each associated with a significant increased risk of aneurysm. Further adjustment for packyears, history of cardiovascular disease and the ankle brachial pressure index resulted in odds ratios of 1.51 (95% CI 1.05 to 2.16, P < or = 0.05) for fibrinogen and 3.75 (95% CI 1.80 to 7.82, P < or = 0.001) for fibrin D-dimer. These associations probably arise as a consequence of fibrin deposition and turnover within the aneurysmal sac, although further prospective studies are needed b...Continue Reading

Citations

Jun 10, 2010·European Heart Journal·Jonathan GolledgePaul E Norman
Dec 3, 2008·Circulation·Jonathan GolledgePaul E Norman
Jul 27, 2007·Circulation Journal : Official Journal of the Japanese Circulation Society·A I Kakafika, D P Mikhailidis
Apr 18, 2002·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·Francesco SerinoAngelo Fusco
Oct 30, 2013·Proceedings of the National Academy of Sciences of the United States of America·Hui-fang ZhouChristine T N Pham
Oct 5, 2010·Thrombosis Research·Hisato TakagiTakuya Umemoto
Jul 11, 2009·The British Journal of Surgery·D J ParryD J A Scott
Jun 30, 2009·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·H TakagiT Umemoto
Apr 24, 2016·Clínica e investigación en arteriosclerosis : publicación oficial de la Sociedad Española de Arteriosclerosis·Carlos LahozUNKNOWN en representación del Grupo de Prevención Secundaria de la Sociedad Española de Arteriosclerosis y de la Sección de Medicina
Jun 15, 2007·Pathophysiology of Haemostasis and Thrombosis·Akihiro IharaHironori Izutani
Dec 20, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Gunnar EngströmFolke Lindgärde

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