Haemostatic management of extreme challenges to haemostasis in acquired von Willebrand syndrome

Haemophilia : the Official Journal of the World Federation of Hemophilia
M P ColellaE V De Paula

Abstract

Acquired von Willebrand syndrome (AVWS) is a rare hemorrhagic condition for which very little information is available regarding the management of extreme challenges to Haemostasis. The AVWS is more common in the elderly, who are frequently exposed to invasive procedures and/or chemotherapy. Haematopoietic stem cell transplantation (HSCT) is a situation in which the haemostatic capacity is challenged by severe thrombocytopaenia, chemotherapy-associated mucosal barrier breakdown and the need for invasive procedures. In our report, we present and discuss the haemostatic management of a patient with AVWS who was refractory to Von Willebrand factor concentrate replacement during the course of an autologous HSCT to treat multiple myeloma. Patients with AVWS are frequently exposed to high-risk haemostatic challenges, and additional information about the haemostatic management of these situations is necessary.

References

Jul 11, 2006·American Journal of Hematology·Hiroshi Mohri
Nov 30, 2006·American Journal of Hematology·Massimo Franchini, Giuseppe Lippi
Jun 25, 2008·Haemophilia : the Official Journal of the World Federation of Hemophilia·P CollinsC M Kessler
Jul 16, 2010·Haemophilia : the Official Journal of the World Federation of Hemophilia·G Dolan
May 5, 2011·Blood·Andreas TiedeAugusto B Federici

❮ Previous
Next ❯

Citations

Apr 5, 2016·Annals of Hematology·Christina DickeFlorian Langer
Jun 2, 2020·Clinical Case Reports·Christophe NicolBrigitte Pan-Petesch

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.