PMID: 7516400Jun 1, 1994Paper

Hailey-Hailey disease is not allelic to Darier's disease

The Journal of Investigative Dermatology
E A WelshE H Epstein

Abstract

Hailey-Hailey (Familial Benign Chronic Pemphigus) Disease is a rare autosomal dominant disorder characterized by blisters caused by suprabasal epidermal acantholysis. Another autosomal dominant skin disease, Darier's disease, has clinical and histologic features which overlap those of Hailey-Hailey disease and recently has been mapped to chromosome 12q23-q24.1. We have used linkage analysis to test whether or not a mutation in this region might also underlie Hailey-Hailey disease. This analysis, using polymorphic loci tightly linked to Darier's disease, excluded this region as the site for the disease-causing mutation in two kindreds affected with Hailey-Hailey disease.

Citations

May 15, 2010·International Journal of Dermatology·R Benmously-MlikaI Mokhtar
Dec 1, 1996·The Journal of Investigative Dermatology·J E CooleyE J O'Keefe

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