Hair analysis for long-term monitoring of buprenorphine intake in opiate withdrawal

Therapeutic Drug Monitoring
Valentina PirroMarco Vincenti

Abstract

Buprenorphine (BUP) is a psychoactive pharmaceutical drug largely used to treat opiate addiction. Short-term therapeutic monitoring is supported by toxicological analysis of blood and urine samples, whereas long-term monitoring by means of hair analysis is rarely used. Aim of this work was to develop and validate a highly sensitive ultrahigh-performance liquid chromatography tandem mass spectrometry method to detect BUP and norbuprenorphine (NBUP) in head hair. Interindividual correlation between oral dosage of BUP and head hair concentration was investigated. Furthermore, an intra-individual study by means of segmental analysis was performed on subjects with variable maintenance dosage. Hair samples from a population of 79 patients in treatment for opiate addiction were analyzed. The validated ultrahigh-performance liquid chromatography tandem mass spectrometry protocol allowed to obtain limits of detection and quantification at 0.6 and 2.2 pg/mg for BUP and 5.0 and 17 pg/mg for NBUP, respectively. Validation criteria were satisfied, assuring selective analyte identification, high detection capability, and precise and accurate quantification. Significant positive correlation was found between constant oral BUP dosage (1-32 mg/...Continue Reading

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May 15, 2013·Therapeutic Drug Monitoring·Pascal Kintz

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Citations

Oct 11, 2015·Journal of Forensic and Legal Medicine·Ping XiangOlaf H Drummer
Jul 15, 2015·Journal of Forensic and Legal Medicine·Marta LeporatiAlberto Salomone
Jun 27, 2018·Journal of Analytical Toxicology·Kamilla Nyborg GüntherKristian Linnet
Aug 2, 2021·Forensic Science International : Synergy·María Cobo-GolpeElena Lendoiro

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