Hair cortisol as a novel biomarker of HPA suppression by inhaled corticosteroids in children

Pediatric Research
Laura SmyGideon Koren

Abstract

Asthma is the most common chronic condition in childhood, and the recommended pharmacotherapy for long-term control includes the use of inhaled corticosteroids (ICS). ICS were designed to act at the site of inflammation in the lung, thus decreasing systemic absorption and reducing the risk of adverse effects associated with corticosteroid use (e.g., HPA suppression and its consequent effects). Available data show that measurement of hair cortisol successfully reflects endogenous cortisol levels. We sought to examine whether hair cortisol measurements can be used to identify HPA suppression surrounding ICS therapy in children with asthma. Hair samples were collected from the vertex posterior region of the head of 18 asthmatic children. We compared their hair cortisol concentration during ICS use with the concentration prior to ICS use. During ICS therapy, median hair cortisol levels were twofold lower compared with the period of no ICS use (median 89.8 ng/g vs. 198.2 ng/g, P = 0.0015). Hair cortisol is an effective biomarker of the HPA suppression associated with ICS therapy and can be a sensitive tool for determining systemic effects of ICS use and monitoring adherence. Future research is needed to characterize the effect of un...Continue Reading

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Citations

Jun 11, 2016·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Brian S LiddellDaniel P Hsu
Aug 24, 2016·The World Allergy Organization Journal·Elham HossnyPeter Le Souef
Jul 18, 2017·Hormone Research in Pædiatrics·Maaike P SmitErica L T van den Akker
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Nov 19, 2019·Current Pediatric Reviews·Nese Akcan, Nerin N Bahceciler
Nov 16, 2020·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Fahad AlahmadiStephen J Fowler
Jan 20, 2021·Pediatric Research·Marcela LopezKanwaljeet J S Anand
Oct 18, 2020·Infant Behavior & Development·Randi A BatesLaura M Justice
Jun 25, 2021·Neurochemistry International·Si-Yu RenNai-Hong Chen

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