Hair cycle-specific immunolocalization of retinoic acid synthesizing enzymes Aldh1a2 and Aldh1a3 indicate complex regulation

The Journal of Investigative Dermatology
Helen B EvertsDavid E Ong

Abstract

Retinoic acid has long been known to alter skin and hair growth but an exact mechanism is unclear. This study was performed to examine the sites of endogenous retinoic acid synthesis in the cycling hair follicle to better understand the role retinoic acid plays in this process. Retinal dehydrogenases (Aldh1a1, 2, and 3, formerly Raldh 1, 2, and 3) are the enzymes responsible for the last step in retinoic acid synthesis. Immunohistochemistry was performed on adult C57BL/6J mouse skin sections with antibodies against Aldh1a2 and Aldh1a3. Aldh1a2 expression was seen primarily in the outer root sheath and basal/spinous layer during all stages of the hair cycle, and in the bulge during anagen and early catagen, whereas Aldh1a3 expression was primarily in the dermal papilla, pre-cortex, and hair shaft during mid-late anagen. The expression patterns of these two similar retinoic acid synthesizing enzymes at specific follicular sites suggest that they mediate and are regulated by different epithelial proliferation and differentiation signaling pathways.

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Citations

Nov 26, 2008·The Journal of Biological Chemistry·Michelle Y S ShihRobert V Farese
Aug 17, 2010·Biochemical and Biophysical Research Communications·Ulrich KoenigErwin Tschachler
Sep 30, 2015·Experimental and Molecular Pathology·Helen B EvertsJohn P Sundberg
Oct 26, 2012·The Journal of Investigative Dermatology·Helen B EvertsJohn P Sundberg
Jun 14, 2005·Experimental Cell Research·Helen B EvertsDavid E Ong
Sep 15, 2011·Biochimica Et Biophysica Acta·Helen B Everts
May 31, 2011·Biochimica Et Biophysica Acta·Joseph L Napoli
Oct 21, 2016·Scientific Reports·Andrea MorettiSilvia Garavaglia
Mar 18, 2011·Experimental Dermatology·Johanna MihályRalph Rühl
Jan 1, 2015·Journal of Animal Science and Technology·Tao ZhongHongping Zhang
Nov 2, 2014·Experimental Biology and Medicine·Liye SuoHelen B Everts
Apr 18, 2019·Journal of Biological Research·Syed Aun MuhammadJake Y Chen
Jan 21, 2021·Nutrients·Helen B Everts, Eleonore-Nausica Akuailou

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