Hair follicle renewal: authentic morphogenesis that depends on a complex progression of stem cell lineages

Development
Emilie LeguéJean-François Nicolas

Abstract

The hair follicle (HF) grows during the anagen phase from precursors in the matrix that give rise to each differentiated HF layer. Little is known about the lineal relationship between these layer-restricted precursors and HF stem cells. To understand how the HF stem cells regenerate the typical anagen organization, we conducted in vivo clonal analysis of key stages of the HF cycle in mice. Unexpectedly, we found that the pool of HF stem cells contains precursors with both multipotent and restricted contributions. This implies that the lineal relationships between HF stem cells (persisting during telogen) and layer-restricted precursors (in the germinative layer), responsible for HF elongation during anagen, are not stereotyped. Formation of the matrix at each cycle is accompanied by the transient expansion of an intermediary pool of precursors at the origin of the germinative layer and by the progressive restriction of cell dispersion. The regionalization of clonal patterns within the outer HF structure (the outer root sheath) suggests that the position of the precursors might be a crucial factor in determining their fate. The presence of HF stem cells with multipotent contribution and the progressive segregation of HF lineage...Continue Reading

References

Jul 18, 1995·Proceedings of the National Academy of Sciences of the United States of America·D MetzgerP Chambon
Oct 1, 1996·Proceedings of the National Academy of Sciences of the United States of America·R FeilP Chambon
Jan 20, 1999·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·T Matsuzaki, K Yoshizato
Apr 14, 1999·The Journal of Investigative Dermatology·R J Morris, C S Potten
Jul 8, 1999·The American Journal of Pathology·A A PanteleyevR Paus
Jan 12, 2001·Physiological Reviews·K S Stenn, R Paus
May 1, 2001·Methods : a Companion to Methods in Enzymology·D Metzger, P Chambon
Jul 10, 2001·The Journal of Investigative Dermatology·S Müller-RöverR Paus
Aug 5, 2003·The Journal of Investigative Dermatology. Symposium Proceedings·Vladimir A Botchkarev, Jiro Kishimoto
Dec 13, 2003·Science·Tudorita TumbarElaine Fuchs
Mar 17, 2004·Nature Biotechnology·Rebecca J MorrisGeorge Cotsarelis
Oct 6, 2005·Proceedings of the National Academy of Sciences of the United States of America·Stéphanie ClaudinotYann Barrandon
May 8, 2007·Seminars in Cell & Developmental Biology·James M WatersColin A B Jahoda
Apr 17, 2008·Genes & Development·Elaine Fuchs, Valerie Horsley
Jul 3, 2008·Cell Stem Cell·Jonathan A NowakElaine Fuchs
Oct 14, 2008·Nature Genetics·Viljar JaksRune Toftgård
Oct 30, 2008·Nature Genetics·Bruce A Morgan
Feb 10, 2009·Cell Stem Cell·Valentina GrecoElaine Fuchs
Feb 13, 2009·Current Biology : CB·Marlon R SchneiderRalf Paus
May 28, 2009·Proceedings of the National Academy of Sciences of the United States of America·Makoto KisoYumiko Saga

❮ Previous
Next ❯

Citations

Jul 27, 2011·Stem Cells and Development·Xusheng WangYaojiong Wu
Dec 24, 2013·Seminars in Cell & Developmental Biology·Panteleimon Rompolas, Valentina Greco
Feb 1, 2012·Stem Cell Reviews and Reports·Tudorita Tumbar
May 30, 2012·The Journal of Cell Biology·Alexandra Van Keymeulen, Cédric Blanpain
Dec 17, 2010·The Journal of Investigative Dermatology·Fiona RugeRebecca M Porter
Mar 13, 2014·Biological Reviews of the Cambridge Philosophical Society·Joseph N Nissimov, Asit Baran Das Chaudhuri
Feb 6, 2017·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Bakr Mohamed El-ZawahryMervat Khorshied
Mar 24, 2016·Toxicologic Pathology·Monika M Welle, Dominique J Wiener
Nov 14, 2018·Nature Cell Biology·Tianchi XinValentina Greco
Sep 4, 2019·American Journal of Human Biology : the Official Journal of the Human Biology Council·Sandra L KochNina G Jablonski
Dec 6, 2020·Experimental Dermatology·Seon A LeeTudorita Tumbar
Dec 29, 2020·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Maik HintzeThomas Franz
Feb 29, 2020·Cell Stem Cell·Simon JoostMaria Kasper
Sep 20, 2012·Development·Inês Sequeira, Jean-François Nicolas
Jul 11, 2021·Indian Journal of Dermatology, Venereology and Leprology·Sujay KhandpurD R Gunaabalaji

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.