PMID: 3745937Jan 1, 1986Paper

Hair follicle response of the golden Syrian hamster flank organ to continuous testosterone stimulation using silastic capsules

The Journal of Investigative Dermatology
A W LuckyB A Nuck

Abstract

The hamster flank organ has served as a model to study androgen-dependent responses of the skin, but the quantitative response of hair follicles to androgenic stimulation has been neglected. We assayed the hair follicle response to testosterone (T) and compared it to the response of the sebaceous glands and of the dermal pigment in the Golden Syrian hamster flank organ. Because of biologic variation in male animals and uneven absorption of hormone from parenteral injections, we implanted silastic capsules 0.25, 0.5, 1, and 2 cm in length filled with crystalline T subcutaneously into female hamsters for 6 weeks. Hair follicle response to T was more sensitive than sebaceous gland or pigment. Diameters of hairs under the sebaceous gland increased significantly from control values of 27.7 +/- 1.0 micron to 38.0 +/- 1.6 micron at the lowest dose of T tested, the 0.25-cm capsule (p less than 0.001). There was an increase in the absolute number of hairs under the sebaceous gland as the flank organ enlarged, from 27.9 +/- 9.9 control to 55.3 +/- 5.8 with the 2-cm T capsule. There was no concomitant increase in hair density, 14.4 +/- 3.5 hairs/mm control vs 12.5 +/- 1.1 hairs/mm with the 2-cm capsule. Hair follicles lateral to the sebac...Continue Reading

Citations

Jun 3, 1999·The British Journal of Dermatology·J A MezickK S Stenn
Jan 1, 1989·Archives of Dermatological Research·F KiesewetterO P Hornstein
Feb 20, 2009·Lasers in Surgery and Medicine·Fernanda H SakamotoR Rox Anderson
Nov 1, 2016·Artificial Cells, Nanomedicine, and Biotechnology·Seyedeh Narjes Yazdani-AraziHamed Hamishehkar
Jun 1, 1991·The Journal of Investigative Dermatology·T SekiK Adachi
Aug 1, 1987·The Journal of Investigative Dermatology·B A Nuck, A W Lucky
Jul 1, 1996·The Journal of Investigative Dermatology·L A PuyF Labrie

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