PMID: 11915519Mar 28, 2002Paper

Hair growth effect of minoxidil

Nihon yakurigaku zasshi. Folia pharmacologica Japonica
Susumu Otomo

Abstract

The length and size of hair are depend on the anagen term in its hair cycle. It has been reported that the some cell growth factors, such as VEGF, FGF-5S, IGF-1 and KGF, induce the proliferation of cells in the matrix, dermal papilla and dermal papillary vascular system and increase the amount of extra cellular matrix in dermal papilla and then maintain follicles in the anagen phase. On the other hand, negative factors, like FGF-5, thrombospondin, or still unknown ones, terminate the anagen phase. If the negative factors become dominant against cell proliferation factors according to fulfilling some time set by the biological clock for hair follicles, TGF beta induced in the matrix tissues evokes apoptosis of matrix cells and shifts the follicles from anagen to catagen. Androgenetic alopecia is caused by miniaturizing of hair follicles located in the frontal or crown part of scalp and are hereditarily more sensitive to androgen. In their hair cycles, the androgen shortens the anagen phase of follicles and shifts them to the catagen phase earlier than usual. The mode of action of hair growth effect of minoxidil is not completely elucidated, but the most plausible explanation proposed here is that minoxidil works as a sulfonylure...Continue Reading

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Citations

Feb 17, 2009·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Hisaharu Yamada, Akiko Ikeda
Feb 17, 2009·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Ryoji Tsuboi
Jan 7, 2014·Biological & Pharmaceutical Bulletin·Jae-Suk ChoiMi-Ryung Kim
Mar 1, 2014·Toxicological Research·Young-Ok ParkYoung-Chul Kim
Mar 3, 2018·International Journal of Molecular Sciences·Nahyun ChoiJong-Hyuk Sung
Aug 26, 2018·International Journal of Cosmetic Science·Alka MadaanManu Jaggi
Feb 15, 2017·BMC Complementary and Alternative Medicine·William A BoisvertBog-Hieu Lee
Sep 9, 2017·Archives of Dermatological Research·Jitlada MeephansanP Suchonwanit
Apr 27, 2010·Journal of Receptor and Signal Transduction Research·Reza Rastmanesh
Apr 12, 2019·Biomolecules & Therapeutics·Nahyun Choi, Jong-Hyuk Sung

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