Hairy Cell Leukemia Presenting with Isolated Skeletal Involvement Successfully Treated by Radiation Therapy and Cladribine: A Case Report and Review of the Literature

Case Reports in Hematology
Ipek Yonal-HindilerdenMeliha Nalcaci

Abstract

We describe an unusual case of hairy cell leukemia (HCL) in a 55-year-old male presenting with isolated skeletal disease as the initial manifestation without abnormal peripheral blood counts, bone marrow involvement, or splenomegaly. To the best of our knowledge, there have been only two previous reports of a similar case. The patient presented with pain in the right femur. Anteroposterior radiographs of both femurs revealed mixed lytic-sclerotic lesions. PET scan showed multiple metastatic lesions on axial skeleton, pelvis, and both femurs. Histopathological examination of the bone biopsy revealed an infiltrate of HCL. Localized radiation therapy to both proximal femurs and subsequently 4 weeks later, a 7-day course of 0.1 mg/kg/day cladribine provided complete remission with relief of symptoms and resolution of bone lesions. We addressed the manifestations and management of HCL patients with skeletal involvement.

References

Jan 1, 1988·Skeletal Radiology·C J HeroldP C Hajek
Aug 1, 1988·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·B C LemberskyH M Golomb
Jun 1, 1985·British Journal of Haematology·K P SchofieldM P Mallick
Nov 1, 1984·Journal of the American Academy of Dermatology·M C FinanC Y Li
Feb 1, 1983·The American Journal of Medicine·J R QuesadaL Llamas
Apr 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M GreverH Golomb
Oct 1, 1995·Seminars in Arthritis and Rheumatism·P HaslerH Gerber
Mar 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M A HoffmanK R Rai
Aug 7, 1998·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·A Di MariaP E Bianchi
Jun 18, 2002·Nature·Helen DaviesP Andrew Futreal
Jan 21, 2003·Leukemia & Lymphoma·A LalLoann Peterson
Sep 23, 2006·Hematology/oncology Clinics of North America·Mark A Hoffman
Oct 23, 2008·Journal of Neurosurgery. Spine·David S RosenBakhtiar Yamini
Oct 22, 2009·Blood·Michael R Grever
Jun 15, 2011·The New England Journal of Medicine·Enrico TiacciBrunangelo Falini
Nov 25, 2011·British Journal of Haematology·Gail JonesUNKNOWN British Committee for Standards in Haematology
Jun 13, 2015·Blood·Sascha DietrichThorsten Zenz

❮ Previous
Next ❯

Citations

May 16, 2020·Blood Research·Sandeep Abhijit PattnaikShruti Mishra
Aug 7, 2020·European Journal of Haematology·Pawel RobakTadeusz Robak

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
biopsies

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Clinical Advances in Hematology & Oncology : H&O
Mehdi Hamadani, Eric H Kraut
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
B C LemberskyH M Golomb
Boletín de la Asociación Médica de Puerto Rico
S N AsmarF Muñiz
© 2022 Meta ULC. All rights reserved