Hairy cell leukemia-variant treated with 2-chlorodeoxyadenosine--a report of three cases

Leukemia & Lymphoma
M Blasińska-MorawiecH Urbańska-Ryś

Abstract

Three patients with B-prolymphocytic variant of HCL (HCL-V) were treated with a chlorinated purine analogue, 2-chlorodeoxyadenosine, at a daily dosage of 0.12 mg/kg in 2-hour intravenous infusion for 5 consecutive days. Partial remission was achieved in only 1 patient, who relapsed after 6 months. Two other patients did not respond to the treatment. HCL-V is a distinct clinicopathological entity which seems to be resistant to various therapeutic modalities. However, further observations are necessary in order to establish the efficacy of 2-CdA in the treatment of HCL-V.

Associated Clinical Trials

May 4, 2006·Robert Kreitman, M.D.Robert Kreitman, M.D.

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Citations

Apr 7, 2009·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Robert J Kreitman
Mar 8, 2000·Leukemia & Lymphoma·S A TetreaultA Saven
Mar 18, 2009·American Journal of Clinical Pathology·Henry Y DongSorina Tugulea
Jun 19, 2010·Cancer Treatment Reviews·Tadeusz Robak
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Sep 26, 2006·Best Practice & Research. Clinical Haematology·Robert J Kreitman, Ira Pastan
Oct 25, 2006·Annual Review of Medicine·Ira PastanRobert J Kreitman
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Jul 28, 2001·The New England Journal of Medicine·R J KreitmanI Pastan
Aug 3, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Robert J KreitmanIra Pastan
Jul 23, 2004·Expert Opinion on Biological Therapy·Robert J Kreitman
Nov 29, 2005·Cancer Immunology, Immunotherapy : CII·Evgeny AronsRobert J Kreitman
Aug 2, 2006·The Oncologist·Sam O Wanko, Carlos de Castro
Aug 13, 2014·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Kaumudi KonkayT Roshni Paul
Sep 28, 2002·Blood Reviews·D J Allsup, J C Cawley
Mar 2, 2005·Archives of Pathology & Laboratory Medicine·Charin Ya-InHong Chang

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