HAL blue-light cystoscopy in high-risk nonmuscle-invasive bladder cancer--re-TURBT recurrence rates in a prospective, randomized study

Urology
Bogdan GeavletePetrisor Geavlete

Abstract

To evaluate the impact of hexaminolevulinate blue-light cystoscopy and transurethral resection of bladder tumors (TURBT) upon the short-term recurrence rate in high-risk nonmuscle-invasive bladder cancer (NMIBC) compared with conventional cystoscopy and resection. Between December 2007 and November 2009, 446 patients were randomized for blue-light cystoscopy/resection and for standard cystoscopy/resection, respectively. The inclusion criteria consisted of positive urinary cytology and ultrasonographic suspicion of bladder tumors. High-risk NMIBC patients (carcinoma in situ [CIS], pTaG3, and pT1) from both series underwent standard Re-TURBT 6 weeks after the initial procedure. The proportions of CIS, pTaG3, and pT1 cases in the initial series were 13.1%, 5.7%, and 22.2% in the blue light series and 11.3%, 5.7%, and 23.3% in the white light series. In total, 72 and 64 high-risk cases, respectively, were diagnosed in the blue- and white-light series. The overall short-term recurrence rate at Re-TURBT was 11.1% for the blue-light group and 31.2% for the white-light group. The recurrence rates were 4.3% versus 27.8% for CIS, 10% versus 22.2% for pTaG3, and 15.4% versus 35.1% for pT1 cases, in favor of the blue-light arm. The recurre...Continue Reading

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Citations

Nov 12, 2010·Nature Reviews. Urology·Tim O'Brien, Kay Thomas
Apr 2, 2013·The Urologic Clinics of North America·Joseph A Gillespie, Michael A O'Donnell
Oct 23, 2012·European Urology·Ashish M KamatUNKNOWN International Consultation on Urologic Disease-European Association of Urology Consultation on Bladder Cancer 2012
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Jul 25, 2019·Photobiomodulation, Photomedicine, and Laser Surgery·Tomasz KoneckiZbigniew Jabłonowski
Oct 31, 2013·Expert Review of Anticancer Therapy·Anna V van LingenJ Alfred Witjes
Oct 13, 2019·International Journal of Urology : Official Journal of the Japanese Urological Association·Hideo Fukuhara
May 27, 2020·International Journal of Clinical Oncology·Hideo FukuharaKeiji Inoue
May 26, 2017·Photomedicine and Laser Surgery·Piotr KutwinZbigniew Jabłonowski

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