PMID: 6410448Jan 1, 1983Paper

Halazepam as a precursor of desmethyldiazepam: quantitation by electron-capture gas-liquid chromatography

Psychopharmacology
D J GreenblattR I Shader

Abstract

Halazepam and its major metabolite desmethyldiazepam (DMDZ) can be reliably quantitated in human plasma following single doses of halazepam. After addition of appropriate internal standards, halazepam and DMDZ are extracted directly into an organic solvent at physiological pH. The organic extract is separated, evaporated to dryness, reconstituted, and directly chromatographed using a 50:50 methyl:phenyl silicone column (SP-2250) and an electron-capture detector. After a single 40 mg oral dose of halazepam, the parent compound appears in plasma only transiently and at low levels. DMDZ appears in higher concentrations and is slowly eliminated. During multiple-dose therapy with halazepam, DMDZ will be the major active substance in blood.

References

Apr 29, 1977·Psychopharmacology·K RickelsJ H Werblowsky
Jun 12, 1982·Lancet·D J GreenblattR I Shader
Jan 1, 1981·British Journal of Clinical Pharmacology·D J GreenblattJ S Harmatz
Aug 1, 1980·Clinical Pharmacology and Therapeutics·M D AllenR I Shader
Jan 1, 1981·British Journal of Clinical Pharmacology·D J GreenblattR I Shader

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Citations

Mar 1, 1991·Pharmacology, Biochemistry, and Behavior·E P WalaT Pruitt
Jul 8, 1988·Journal of Chromatography·S K Gupta, E H Ellinwood
Jan 1, 1986·European Journal of Clinical Pharmacology·W D Bechtel, E Goetzke
Sep 1, 1990·Journal of Pharmaceutical Sciences·S K Gupta, E H Ellinwood
Aug 29, 2020·Journal of Clinical Pharmacology·David J GreenblattRichard I Shader

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