HALF-DOSE PHOTODYNAMIC THERAPY COMBINED WITH BEVACIZUMAB FOR POLYPOIDAL CHOROIDAL VASCULOPATHY

Retina
Jae Hyung Lee, Won Ki Lee

Abstract

To evaluate the efficacy of half-dose photodynamic therapy (PDT) combined with intravitreal bevacizumab (IVB) for polypoidal choroidal vasculopathy. For this retrospective comparative study, data from 57 patients (63 eyes) with at least 12 months of follow-up were reviewed. Full-dose or half-dose PDT combined with a single IVB treatment was performed according to the time period. From 3 months after the initial combination treatment, retreatment was performed mainly using anti-vascular endothelial growth factor injections on an as-needed basis. Consecutively, 33 eyes were treated with full-dose PDT/IVB and 30 eyes with half-dose PDT/IVB. At Month 3, half-dose PDT/IVB induced negligible damage to the physiologic choroid but was inferior to full-dose PDT/IVB in achieving complete polyp closure (43.3% vs. 72.7%, P = 0.018) and improving mean best-corrected visual acuity (20/66 vs. 20/43, P = 0.020). At Month 12, the half-dose group achieved comparable visual improvement (20/51 vs. 20/40, P = 0.254) but required more additional injections (a mean of 2.80 vs. 1.03, P = 0.004). Despite inferior efficacy in inducing polyp closure, half-dose PDT/IVB followed by additional injections showed promising visual outcomes while avoiding damag...Continue Reading

References

Sep 25, 2002·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Ursula Schlötzer-SchrehardtUrsula Schmidt-Erfurth
Apr 26, 2003·Investigative Ophthalmology & Visual Science·Stephan Michels, Ursula Schmidt-Erfurth
Sep 26, 2003·Investigative Ophthalmology & Visual Science·Ursula Schmidt-ErfurthGottfried O H Naumann
May 3, 2005·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Rufino M SilvaJ G Cunha-Vaz
Dec 31, 2005·Investigative Ophthalmology & Visual Science·Stephan MichelsUrsula Schmidt-Erfurth
Jun 14, 2006·Archives of Ophthalmology·Olcay TatarSalvatore Grisanti
Apr 18, 2007·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Kaori SayanagiYasuo Tano
May 1, 2007·American Journal of Ophthalmology·Atsushi OtaniNagahisa Yoshimura
Jul 11, 2008·American Journal of Ophthalmology·Yumiko KurashigeNagahisa Yoshimura
Jan 1, 2010·American Journal of Ophthalmology·Ayana YamashitaKaori Tenkumo
Feb 19, 2011·Japanese Journal of Ophthalmology·Eriko AkazaRyusaburo Mori
Sep 22, 2012·American Journal of Ophthalmology·Ayana YamashitaAtsushi Fujiwara

❮ Previous
Next ❯

Citations

Apr 21, 2016·Progress in Retinal and Eye Research·Chee Wai WongChui Ming Gemmy Cheung

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.