Half-Dose Photodynamic Therapy versus High-Density Subthreshold Micropulse Laser Treatment in Patients with Chronic Central Serous Chorioretinopathy: The PLACE Trial

Ophthalmology
Elon H C van DijkCamiel J F Boon

Abstract

To compare the anatomic and functional efficacy and safety of half-dose photodynamic therapy (PDT) versus high-density subthreshold micropulse laser (HSML) treatment in patients with chronic central serous chorioretinopathy (cCSC). Open-label, multicenter, randomized controlled clinical trial. Patients with cCSC whose disease had to be confirmed by both clinical characteristics and findings on multimodal imaging. Eligible patients were randomized in a 1:1 allocation ratio. Treatment was evaluated during a follow-up visit, and the same treatment was repeated in patients who still demonstrated subretinal fluid (SRF). The primary end point was the complete disappearance of SRF at the first evaluation visit at 6 to 8 weeks after treatment. As a secondary outcome measure, we assessed this anatomic result at the final evaluation visit at 7 to 8 months after treatment. Other secondary outcomes covered functional improvement and included change in best-corrected visual acuity (BCVA; measured in Early Treatment Diabetic Retinopathy Study [ETDRS] letters), retinal sensitivity (measured using microperimetry), and vision-related quality of life using a validated questionnaire. Between November 2013 and September 2016, 179 patients were inc...Continue Reading

Citations

Jan 25, 2019·Current Pharmaceutical Design·Pierluigi IaconoMaria Cristina Parravano
Mar 12, 2020·Clinical Ophthalmology·Keissy SousaManuel Falcão
Aug 7, 2019·Investigative Ophthalmology & Visual Science·Rosa L SchellevisAnneke I den Hollander
Mar 1, 2020·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Benedikt SchwormJakob Siedlecki
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May 28, 2019·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Thomas J van RijssenCamiel J F Boon
Sep 11, 2019·Journal of Clinical Medicine·Maciej GawęckiAndrzej Grzybowski
Apr 13, 2020·Ophthalmology and Therapy·Elon H C van DijkCamiel J F Boon
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Oct 30, 2020·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Thomas J van RijssenCamiel J F Boon
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Mar 16, 2021·Progress in Retinal and Eye Research·Elon H C van Dijk, Camiel J F Boon

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