Half-dose vs one-third-dose photodynamic therapy for chronic central serous chorioretinopathy.

Eye
R UetaniH Terasaki

Abstract

To prospectively compare the effects of half-dose verteporfin (3 mg/m(2)) photodynamic therapy (1/2 PDT) with those of one-third-dose verteporfin (2 mg/m(2)) PDT (1/3 PDT) for chronic central serous chorioretinopathy (CSC). Sixteen eyes of 16 consecutive patients with chronic CSC were enrolled and followed up for a 3-month study period. The first 10 patients received 1/2 PDT and the next 6 patients received 1/3 PDT. The resolution rate of subretinal fluid (SRF) was compared between the two groups. The changes in the choroidal thickness inside and outside the PDT-applied area in both groups were also evaluated. SRF disappeared in all eyes (100%) in the 1/2 PDT group and in two eyes (33%) in the 1/3 PDT group. In the 1/2 PDT group, choroidal thickness inside and outside the PDT-applied area reduced significantly from the baseline (inside, from 387 ± 24 to 325 ± 25 μm; outside, from 292 ± 25 to 249 ± 19 μm; both P=0.005). In the 1/3 PDT group, choroidal thickness decreased in two eyes where SRF disappeared (inside, 87.2 and 90.9% of the baseline; outside, 91.4 and 92.6% of the baseline), but did not change in the other four eyes where SRF remained (inside, 104.1, 100.0, 105.1, and 100.5% of the baseline; outside, 98.9, 103.0, 100....Continue Reading

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Citations

Mar 7, 2014·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Chun-Fu LiuLing Yeung
Jun 21, 2014·Eye·O C ErikitolaS Sivaprasad
Feb 4, 2014·American Journal of Ophthalmology·Massimo NicolóFelice Cardillo Piccolino
Nov 21, 2015·Saudi Journal of Ophthalmology : Official Journal of the Saudi Ophthalmological Society·Marwan A Abouammoh
Jan 27, 2015·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Yong-Kyu KimKyu Hyung Park
Jan 21, 2014·Ophthalmology·Jennifer I LimUNKNOWN Macula Society CSC Collaborative Study Group, Research and Education Committee and Website Committee
Jun 1, 2015·Progress in Retinal and Eye Research·Alejandra DaruichFrancine Behar-Cohen
Jul 9, 2013·American Journal of Ophthalmology·Abdallah A EllabbanNagahisa Yoshimura
May 26, 2015·Acta Biomaterialia·Xiaolei ZhouMingdong Huang
Apr 30, 2016·Photodiagnosis and Photodynamic Therapy·Filipe NevesLuís Agrelos
Dec 23, 2015·The Cochrane Database of Systematic Reviews·Mahsa SalehiPeter Gehlbach
Jul 31, 2020·The British Journal of Ophthalmology·Dong-Geun ParkMin Sagong
Sep 12, 2020·Ceská a slovenská oftalmologie : casopis Ceské oftalmologické spolecnosti a Slovenské oftalmologické spolecnosti·K ManethováN Jirásková
Jul 1, 2013·Asia-Pacific Journal of Ophthalmology·Neelakshi Bhagat, Marco Zarbin
Jul 19, 2019·Progress in Retinal and Eye Research·Thomas J van RijssenCamiel J F Boon
Sep 7, 2020·Archivos de la Sociedad Española de Oftalmología·F J Moreno-MorilloJ Donate-López

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