Half-inhibition concentrations of new cholinesterase inhibitors

Zeitschrift Für Naturforschung. C, a Journal of Biosciences
P ZdrazilováAlexander Cegan

Abstract

The power of chosen carbamates and hydrazinium derivatives (carbazates) to inhibit the hydrolysis of acetylthiocholine by butyrylcholinesterase or acetylcholinesterase was tested. The determined pI50 values (= negative logarithm of the molar concentration inhibiting the enzyme activity by 50%) of the tested substances were compared with pI50 values of the commercially used drugs for the Alzheimer's disease treatment--rivastigmine and galanthamine.

Citations

Feb 16, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Martin KrátkýJarmila Vinšová
Jul 30, 2005·World Journal of Gastroenterology : WJG·Shan-Zhi GuBo-Rong Pan
Jun 3, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jarmila VinšováJiřina Stolaříková
Aug 28, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ales ImramovskyJosef Jampilek
Nov 15, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hana PizovaJosef Jampilek
Apr 3, 2019·International Journal of Molecular Sciences·Andrzej BakJosef Jampilek
Nov 2, 2019·International Journal of Molecular Sciences·Andrzej BakJosef Jampilek
Aug 21, 2020·Current Topics in Medicinal Chemistry·Martin KrátkýJarmila Vinšová
Aug 21, 2020·Current Topics in Medicinal Chemistry·Martin KrátkýJarmila Vinšová
Mar 7, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Martin KrátkýJarmila Vinšová

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Zeitschrift Für Naturforschung. C, a Journal of Biosciences
Sárka StepánkováAlexander Cegan
Zeitschrift Für Naturforschung. C, a Journal of Biosciences
P ZdrazilováAlexander Cegan
Zhongguo yao li xue bao = Acta pharmacologica Sinica
B J Yuan, B Y Qin
© 2022 Meta ULC. All rights reserved