Halloysite and chitosan oligosaccharide nanocomposite for wound healing

Acta Biomaterialia
G SandriF Ferrari

Abstract

Halloysite is a natural nanotubular clay mineral (HNTs, Halloysite Nano Tubes) chemically identical to kaolinite and, due to its good biocompatibility, is an attractive nanomaterial for a vast range of biological applications. Chitosan oligosaccharides are homo- or heterooligomers of N-acetylglucosamine and D-glucosamine, that accelerate wound healing by enhancing the functions of inflammatory and repairing cells. The aim of the work was the development of a nanocomposite based on HNTs and chitosan oligosaccharides, to be used as pour powder to enhance healing in the treatment of chronic wounds. A 1:0.05 wt ratio HTNs/chitosan oligosaccharide nanocomposite was obtained by simply stirring the HTNs powder in a 1% w/w aqueous chitosan oligosaccharide solution and was formed by spontaneous ionic interaction resulting in 98.6% w/w HTNs and 1.4% w/w chitosan oligosaccharide composition. Advanced electron microscopy techniques were considered to confirm the structure of the hybrid nanotubes. Both HTNs and HTNs/chitosan oligosaccharide nanocomposite showed good in vitro biocompatibility with normal human dermal fibroblasts up to 300μg/ml concentration and enhanced in vitro fibroblast motility, promoting both proliferation and migration...Continue Reading

Citations

Jul 13, 2017·Current Medicinal Chemistry·Marieke Haalboom
Jun 20, 2019·Expert Opinion on Drug Delivery·Barbara ViganiFranca Ferrari
Feb 26, 2020·Pharmaceutics·Giuseppina SandriFranca Ferrari
Jul 20, 2019·Nanobiomedicine·Swathi SatishDeepak Rawtani
Aug 30, 2018·Npj Regenerative Medicine·Abigail M SpearRory F Rickard
Apr 9, 2020·Pharmaceutics·Angela FaccendiniFraanca Ferrari
Mar 2, 2019·Journal of Biomedical Materials Research. Part a·Esperanza CarazoCarola Aguzzi
Jan 23, 2020·Marine Drugs·Mitchell JonesAlexander Bismarck
Sep 6, 2019·Expert Opinion on Drug Delivery·Ana Cláudia SantosYuri Lvov
May 28, 2020·Pharmaceutics·Fátima García-VillénGiuseppina Sandri
Jul 20, 2019·Journal of Biomaterials Science. Polymer Edition·Rafaella S S ZanetteMichele Munk
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Mar 27, 2021·Carbohydrate Polymers·Nishat TabassumM Azam Ali
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Aug 5, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yang ZhouJun Wu
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