Halloysite Nanotubes-Induced Al Accumulation and Fibrotic Response in Lung of Mice after 30-Day Repeated Oral Administration

Journal of Agricultural and Food Chemistry
Xue WangXiaolong Xu

Abstract

Natural halloysite (Al2Si2O5(OH)4· nH2O) nanotubes (HNT) are clay materials with hollow tubular structure and are widely applied in many fields. Many in vitro studies indicate that HNTs exhibit a high level of biocompatibility; however, the in vivo toxicity of HNTs remains unclear. In this study, the biodistribution and pulmonary toxicity of the purified HNTs in mice were investigated after intragastric administration for 30 days. HNTs have high stability in biological conditions. Oral administration of HNTs caused significant Al accumulation predominantly in the lung with relative slight effects on Si biodistribution. Oral administration of HNTs stimulated the growth of the mice at low dose (5 mg/kg BW) with no pulmonary toxicity but inhibited the mouse growth and resulted in oxidative stress and inflammation in lung at high dose (50 mg/kg BW). In addition, oral HNTs at high dose could be absorbed from the gastrointestinal tract and deposited in lung and could also induce pulmonary fibrosis.

References

Jan 1, 1986·Ciba Foundation Symposium·J W Dobbie, M B Smith
Sep 16, 2000·Inhalation Toxicology·R B SchlesingerM Ménache
Aug 19, 2003·Journal of Chemical Ecology·M J Wilson
Feb 11, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Takashi KuwanoMayumi Ono
Feb 4, 2009·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Bin XuJing-Hua Yang
Feb 23, 2010·Biomacromolecules·Viviana VergaroStefano Leporatti
Mar 5, 2011·Particle and Fibre Toxicology·Igor PujaltéBéatrice L'Azou
Jan 1, 2010·Nano Reviews·Neenu SinghShareen H Doak
Jul 20, 2012·International Journal of Nanomedicine·Chang-Moon LeeSeok Tae Lim
Apr 23, 2013·Journal of Applied Toxicology : JAT·Xianyin LaiFrank A Witzmann
Apr 2, 2014·Particle and Fibre Toxicology·Andrea Adamcakova-DoddPeter S Thorne
Jul 22, 2014·Environmental Health : a Global Access Science Source·Guillaume BoulangerMarie-Claude Jaurand
Dec 9, 2014·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Shutong YinZhongyu Li
Aug 5, 2015·Colloids and Surfaces. B, Biointerfaces·Farrukh Rafiq AhmedAhsana Dar
Sep 4, 2015·Journal of Agricultural and Food Chemistry·Xincheng YanXiaolong Xu
Oct 7, 2015·Advanced Materials·Yuri LvovRawil Fakhrullin
Feb 27, 2016·Environmental Toxicology and Chemistry·Lorenza BellaniMarina Massaro
Mar 2, 2016·Particle and Fibre Toxicology·Giulia ViettiSybille van den Brule
May 26, 2015·Nanomaterials·Giuseppe Chichiriccò, Anna Poma
Apr 7, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Marina MassaroRiccardo Amorati
May 7, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·C RizzoM Massaro
Apr 28, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·M MassaroS Riela

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Citations

Oct 24, 2018·Journal of Functional Biomaterials·Giuseppe CavallaroFilippo Parisi
Nov 28, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Zheru LongMingxian Liu
Aug 14, 2020·Polymers·Lorenzo LisuzzoGiuseppe Lazzara
Sep 6, 2019·Expert Opinion on Drug Delivery·Ana Cláudia SantosYuri Lvov
Nov 26, 2020·Nanoscale·Ofer Prinz Setter, Ester Segal
Mar 24, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Giuseppe CavallaroGiuseppe Lazzara
May 7, 2020·ACS Applied Materials & Interfaces·Giuseppe CavallaroYuri Lvov
Apr 6, 2021·Advances in Colloid and Interface Science·Irina PereiraAna Cláudia Paiva-Santos
Jun 3, 2021·Materials·Anna KarewiczGabriela Ledwójcik
Jun 5, 2021·ACS Applied Bio Materials·Ofer Prinz SetterEster Segal

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