Halo nevus, rather than vitiligo, is a typical dermatologic finding of turner's syndrome: clinical, genetic, and immunogenetic study in 72 patients

Journal of the American Academy of Dermatology
Valeria BrazzelliGiovanni Borroni

Abstract

Turner's syndrome (TS) is a genetic disorder caused by numeric and/or structural abnormalities of the X chromosome; it is characterized by short stature, gonadal dysgenesis, and frequently by webbed neck, cubitus valgus, and lymphedema at birth. TS has been associated with several cutaneous abnormalities including an increased frequency of pigmented nevi, but few reports consider nevi in detail. Halo nevus (HN) is clinically defined as a melanocytic nevus surrounded by a halo of depigmentation. Vitiligo, a dermatologic disorder characterized by the presence of depigmented patches on the skin, has been described in the list of cutaneous findings associated with TS. The aim of this study was to determine the prevalence of HN and vitiligo in TS and to evaluate if a correlation between major histocompatibility complex genes, karyotype, autoimmunity, therapies, and the presence of HN exists. Of the 72 patients with TS examined, 13 had HN, a prevalence of 18.05%, which was significantly higher than in our control group (1%; P=.000001). On the contrary, only 2 patients with TS (2.77%, P=not significant) had vitiligo. By comparing the distribution of HLA class I alleles between patients with TS who did (13 of 72) and did not (59 of 72)...Continue Reading

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Citations

Jul 27, 2010·Pediatric Dermatology·Cristina E Bello-QuinteroElizabeth Alvarez-Connelly
May 17, 2006·Clinical Pediatrics·Brandy H DoswellJohn M Graham
Oct 3, 2007·The Journal of Dermatology·Naoki OisoAkira Kawada
Aug 17, 2019·American Journal of Medical Genetics. Part a·Angela E LinClaus H Gravholt
Mar 16, 2012·Journal of the European Academy of Dermatology and Venereology : JEADV·A PatriziI Neri
Apr 13, 2013·Clinical Genetics·M VreeburgD Marcus-Soekarman
Dec 20, 2011·Histopathology·Thomas Brenn
May 31, 2016·The Journal of Dermatology·Takako Miura, Toshiyuki Yamamoto
May 26, 2016·Journal of Endocrinological Investigation·M CappaUNKNOWN GeNeSIS National Board on behalf of the GeNeSIS Italian Investigators
Oct 8, 2011·International Journal of Immunopathology and Pharmacology·Valeria BrazzelliG Borroni
Jul 15, 2017·European Journal of Endocrinology·Claus H GravholtUNKNOWN International Turner Syndrome Consensus Group
Nov 18, 2015·Pediatric Dermatology·Brandon E CohenSeth J Orlow
Aug 17, 2019·Frontiers in Endocrinology·Malgorzata WegielAneta Gawlik
Oct 17, 2020·The Journal of Dermatology·Emi YamazakiSetsuya Aiba

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