PMID: 6162160Dec 20, 1980Paper

Halogenation of tubercidin by N-halosuccinimides. A direct route to 5-bromotubercidin, a reversible inhibitor of RNA synthesis in eukaryotic cells

Nucleic Acids Research
D E Bergstrom, A J Brattesani

Abstract

Tubercidin may be directly brominated by reaction with N-bromosuccinimide in DMF to give 5-bromotubercidin, a reversible inhibitor of RNA synthesis. When buffered with potassium acetate the major product is 6-bromotubercidin. 5,6-Dibromotubercidin is formed in minor amounts under both conditions. N-Chlorosuccinimide and tubercidin give 5-chlorotubercidin and 5,6-dichlorotubercidin.

References

Jan 1, 1970·Experientia·P C Srivastava, K Nagpal

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Citations

Feb 12, 2002·Bioorganic & Medicinal Chemistry·Liangren ZhangLihe Zhang
Jun 24, 2008·Nucleosides, Nucleotides & Nucleic Acids·Nunzia CilibertiSilvia Vertuani
Nov 27, 2001·Nucleosides, Nucleotides & Nucleic Acids·K S GudmundssonP L Feldman
Mar 27, 2004·Nucleosides, Nucleotides & Nucleic Acids·Xiaojing WangMichael T Migawa

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