PMID: 6540296Sep 1, 1984Paper

Haloperidol and cerebral metabolism in the conscious rat: relation to pharmacokinetics

Journal of Neurochemistry
G PizzolatoS I Rapoport

Abstract

The time course and distribution of alterations in cerebral metabolic activity after haloperidol administration were evaluated in relation to the pharmacokinetics of haloperidol and the topography of the dopaminergic system in the brain. Local cerebral glucose utilization was measured, using the 2-deoxyglucose technique, in awake rats after i.p. administration of the dopamine antagonist haloperidol (0.5 or 1 mg/kg). Haloperidol significantly reduced glucose utilization in 60% of 59 brain regions examined, but produced a large increase in the lateral habenula. The regional distribution of changes in glucose utilization was not closely related to the known anatomy of the brain dopaminergic system. The time course of the effect of haloperidol on cerebral metabolism was different for the two doses studied (0.5 and 1 mg/kg), and was not simply related to estimated brain concentrations of haloperidol. However, a linear relation between the metabolic effect and the time-integrated brain concentration was demonstrated. These results show that haloperidol has an effect on CNS metabolic activity that is more widespread than would be predicted from the topography of the dopaminergic system; this may be due to indirect propagation of the p...Continue Reading

References

Jan 15, 1977·The Journal of Comparative Neurology·J E Krettek, J L Price
Jan 11, 1979·Nature·J W Kebabian, D B Calne
Feb 1, 1979·The Journal of Comparative Neurology·M Herkenham
Nov 2, 1973·Science·A M ThierryJ Glowinski
May 1, 1974·The Journal of Comparative Neurology·V M PickelF E Bloom
Feb 1, 1983·Journal of Neurochemistry·C D ArnettR R MacGregor
Jan 28, 1982·Brain Research·K IshikawaJ L McGaugh
Aug 8, 1980·European Journal of Pharmacology·A J Cross, F Owen

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Citations

Mar 22, 2005·Psychopharmacology·C A StewardY B Shah
Nov 18, 1985·Brain Research·T T SoncrantS I Rapoport
May 1, 1994·Brain Research. Brain Research Reviews·G Ellison
Dec 3, 2010·Journal of Crohn's & Colitis·Gert Van AsscheUNKNOWN European Crohn's and Colitis Organisation (ECCO)
Aug 5, 2003·Pharmacology, Biochemistry, and Behavior·Isabelle M Maisonneuve, Stanley D Glick
Feb 7, 1998·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·J A PrinceL Oreland
Jan 1, 1988·Experimental Aging Research·D G Hazzard, J Soban
Oct 1, 1986·Journal of Neurology, Neurosurgery, and Psychiatry·N D VolkowR Cancro
Nov 27, 2015·Proteomics·Klaus Oliver SchubertDavid R Cotter
Mar 26, 1986·Brain Research·T T SoncrantS I Rapoport
Jan 1, 1986·Computers in Biology and Medicine·T T Soncrant
Dec 29, 1989·Brain Research·A della Puppa, E D London
Nov 21, 2012·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Natalia GassWolfgang Weber-Fahr
Dec 1, 1988·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·G PizzolatoL Battistin
Jan 1, 1990·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·D McNamaraT T Soncrant
Oct 1, 1988·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·T T SoncrantS I Rapoport
Mar 10, 2004·Behavioral and Cognitive Neuroscience Reviews·J Shumake, F Gonzalez-Lima
Oct 22, 2002·The Journal of Pharmacology and Experimental Therapeutics·Takanori EsakiLouis Sokoloff
Jul 12, 2011·The Journal of Pharmacology and Experimental Therapeutics·Stefanie DedeurwaerdereXavier Langlois
Apr 10, 2020·Nature Reviews. Neuroscience·Hailan HuYan Yang
Feb 23, 2017·Neuroscience and Biobehavioral Reviews·Marc Fakhoury

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