Haloperidol and sudden cardiac death in dementia: autopsy findings in psychiatric inpatients

International Journal of Geriatric Psychiatry
Petru IfteniPeter Manu

Abstract

Treatment with haloperidol has been shown, in studies using death certificates and prescription files, to be associated with an excess of sudden cardiac deaths, and regulatory warnings highlight this risk in patients with dementia. We used autopsy findings to determine whether the rate of sudden cardiac death is greater in cases of unexpected deaths of patients with dementia treated with haloperidol. From 1989 through 2013, 1219 patients with a primary diagnosis of dementia with behavioral disturbance were admitted to a psychiatric hospital, and 65 (5.3%) died suddenly. Sixty-five patients (5.3%) died unexpectedly. Complete post-mortem examinations after the sudden death were performed in 55 (84.6%) patients. Twenty-seven of the autopsied cases (49.1%) had been treated with haloperidol orally (2.2 mg ± 2.1 mg/day), the only antipsychotic used in this cohort. Univariable comparisons and multivariable regression analyses compared the groups of patients with or without sudden cardiac death. The leading causes of death were sudden cardiac death (32.7%), myocardial infarction (25.5% of patients), pneumonia (23.6%), and stroke (10.9%). Patients with sudden cardiac death and those with anatomically established cause of death were simi...Continue Reading

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Citations

Mar 10, 2016·Journal of Clinical Pharmacology·H Karl Greenblatt, David J Greenblatt
Feb 6, 2018·American Journal of Therapeutics·Andreea TeodorescuLiliana M Rogozea
Jan 24, 2020·Neuropsychiatrie : Klinik, Diagnostik, Therapie und Rehabilitation : Organ der Gesellschaft Österreichischer Nervenärzte und Psychiater·Éva RáskyChristian Jagsch
Dec 16, 2016·The American Journal of Forensic Medicine and Pathology·Petru IfteniLaura Dracea

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