Haloperidol attenuates Methylphenidate and Modafinil induced behavioural sensitization and cognitive enhancement

Metabolic Brain Disease
Nausheen Alam, Kulsoom Choudhary

Abstract

Previous studies have demonstrated that repeated psychostimulant administration produces behavioural sensitization and cognitive tolerance. Brain dopaminergic system and the involvement of dopamine D2-receptors are considered to be important in psychostimulant-induced sensitization. Study designed to compared the motor activity by using familiar and novel enviroments and cognitive effects by water maze and passive avoidance test after long term administration of methylphenidate(at the dose 0.6 mg/kg/day, 2.5 mg/kg/day and 10 mg/kg/day) and modafinil (50 mg/kg/day, 64 mg/kg/day and 75 mg/kg/day) in rats. The effects of challenge dose of haloperidol (at the dose of 1 mg/kg i.p.) has monitored to visualize any subsensitization or supersensitization of D2 receptors. We found that motor activity and cognitive performance was increased in all doses and sensitization effect was more pronounced after 13 days of drug administration were greater at high than low and medium doses.Challenge dose of haloperidol attenuate motor activity in familiar and novel environment and impaired cognition in water maze and passive avoidance test in all treated rats. The effect of Haloperidol in high dose treated rats were however somewhat greater than lo...Continue Reading

References

Sep 1, 1993·Brain Research. Brain Research Reviews·T E Robinson, K C Berridge
May 19, 1998·Journal of Psychopharmacology·P W KalivasB A Sorg
Sep 6, 2000·Pharmacology, Biochemistry, and Behavior·S Schenk, B Partridge
Nov 28, 2001·The European Journal of Neuroscience·L J VanderschurenA N Schoffelmeer
Mar 28, 2006·Pharmacology, Biochemistry, and Behavior·Jeremy J Clark, Ilene L Bernstein
May 4, 2006·The Journal of Clinical Psychiatry·Jacob S Ballon, David Feifel
Jul 18, 2006·Current Pharmaceutical Design·Nancy J Wesensten
Jan 26, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jean-Martin BeaulieuMarc G Caron
Jun 1, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Theo HatzipetrosBryan K Yamamoto
Aug 23, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Michael J Minzenberg, Cameron S Carter
Aug 22, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Wei-Min QuYoshihiro Urade
Mar 19, 2009·JAMA : the Journal of the American Medical Association·Nora D VolkowKaren Apelskog-Torres
Apr 17, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Philip L ClatworthyTrevor W Robbins
Sep 18, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Emmanuel ValjentJean-Antoine Girault
Jan 4, 2012·Physiology & Behavior·Katherine M SerafineAnthony L Riley
Jan 11, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Brooke E Schmeichel, Craig W Berridge
Aug 21, 2013·Neuropharmacology·Vanessa Athaíde GarciaNadja Schröder
Dec 17, 2014·Biological Psychiatry·Robert C SpencerCraig W Berridge
Feb 3, 2015·Pharmacology, Biochemistry, and Behavior·Panayotis K ThanosNora D Volkow
Jul 2, 2015·International Neurourology Journal·Khae Hawn KimSung Tae Cho

❮ Previous
Next ❯

Software Mentioned

statistical package for social sciences

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here