Haloperidol Concentrations in Patients With Alzheimer's Dementia

The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry
M W DyskenS Skare

Abstract

To investigate the relationship between clinical response and haloperidol blood concentrations in Alzheimer's dementia (AD) patients with behavior problems, 29 AD inpatients were assigned to a fixed oral dosage of haloperidol (0.5 mg, 1.0 mg, or 2.0 mg) every 12 hours for 3 weeks. BEHAVE-AD ratings and concentrations of plasma and RBC haloperidol and reduced haloperidol were obtained on Days 8, 15, and 22. Although no significant linear or curvilinear relationships were apparent between percent of change on BEHAVE-AD and plasma or RBC haloperidol concentrations, a good response (change ≥ 30%) was observed in 55% of the patients who entered the study.

Citations

Jul 1, 1996·Journal of Geriatric Psychiatry and Neurology·M S Lantz, D Marin
Nov 1, 2001·The Cochrane Database of Systematic Reviews·E LonerganJ Colford

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