Haloperidol Interactions with the dop-3 Receptor in Caenorhabditis elegans

Molecular Neurobiology
Bárbara Nunes KrumMichael Aschner

Abstract

Haloperidol is a typical antipsychotic drug commonly used to treat a broad range of psychiatric disorders related to dysregulations in the neurotransmitter dopamine (DA). DA modulates important physiologic functions and perturbations in Caenorhabditis elegans (C. elegans) and, its signaling have been associated with alterations in behavioral, molecular, and morphologic properties in C. elegans. Here, we evaluated the possible involvement of dopaminergic receptors in the onset of these alterations followed by haloperidol exposure. Haloperidol increased lifespan and decreased locomotor behavior (basal slowing response, BSR, and locomotion speed via forward speed) of the worms. Moreover, locomotion speed recovered to basal conditions upon haloperidol withdrawal. Haloperidol also decreased DA levels, but it did not alter neither dop-1, dop-2, and dop-3 gene expression, nor CEP dopaminergic neurons' morphology. These effects are likely due to haloperidol's antagonism of the D2-type DA receptor, dop-3. Furthermore, this antagonism appears to affect mechanistic pathways involved in the modulation and signaling of neurotransmitters such as octopamine, acetylcholine, and GABA, which may underlie at least in part haloperidol's effects. T...Continue Reading

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Citations

Jan 12, 2021·Neurobiology of Disease·Antonio Dominguez-MeijideTiago Fleming Outeiro

Methods Mentioned

BETA
transgenic
reverse transcription PCR
PCR

Related Concepts

Acetylcholine
Mental Disorders
Dopamine
Gamma-Aminobutyric Acid
Gene Expression
Haloperidol
Helminths
Locomotion
Neurotransmitters
Octopamine

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