Haloperidol promotes proliferation but inhibits differentiation in rat oligodendrocyte progenitor cell cultures

Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire
Jianqin NiuLan Xiao

Abstract

Haloperidol is a commonly used, typical, antipsychotic drug (APD) that acts strongly against positive symptoms, but has fewer therapeutic effects on, or may even aggravate, negative symptoms and cognitive deficits in patients with schizophrenia. Loss of oligodendrocytes has been suggested as a factor associated with the negative symptoms of schizophrenia. Recent study shows that chronic haloperidol treatment induced down-regulation of oligodendrocyte-related genes in certain brain regions of mouse. In this study, we used primary oligodendrocyte progenitor cell cultures from 1- to 3-day-postnatal rats to investigate the direct effects of haloperidol on the proliferation and differentiation of oligodendrocyte progenitor cells. Our results showed that (i) haloperidol (0-10.0 micromol.L-1) facilitated the proliferation of oligodendrocyte progenitor cells, (ii) chronic haloperidol (0.5 micromol.L-1) treatment decreased the number of myelin basic protein positive oligodendrocytes and reduced the oligodendrocytes cells possessing myelin-like membranes, resulting in inhibition of the terminal differentiation of oligodendrocytes, and (iii) D3 receptor mRNA was detected in oligodendrocyte progenitor cells, and haloperidol treatment induc...Continue Reading

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Citations

Feb 18, 2011·European Archives of Psychiatry and Clinical Neuroscience·Johann SteinerGerburg Keilhoff
Jun 4, 2013·European Archives of Psychiatry and Clinical Neuroscience·Haiyun XuXin-Min Li
Nov 21, 2012·The International Journal of Neuropsychopharmacology·Yuan RenLan Xiao
Feb 3, 2018·European Archives of Psychiatry and Clinical Neuroscience·Valéria de Almeida, Daniel Martins-de-Souza
Jul 5, 2011·Expert Review of Neurotherapeutics·Mark WalterfangChristos Pantelis
May 23, 2013·Journal of Neurochemistry·Chengren LiJiming Kong
May 20, 2020·Frontiers in Psychiatry·Danielle Gouvêa-JunqueiraFernanda Crunfli

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