PMID: 9176643May 1, 1997Paper

Halothane administration during liquid ventilation

Respiratory Medicine
D B Kimless-GarberThomas H Shaffer

Abstract

The objective of this study was to test the hypothesis that perfluorochemical (PFC) liquid ventilation (LV) can be used as a vehicle to deliver halothane and induce and maintain analgesia. Seven hamsters were paralysed and stabilized with mechanical gas ventilation, ventilated in alternating cycles with gas and either neat oxygenated PFC liquid or oxygenated PFC liquid mixed with liquid halothane (PFC:hal) 1:50% (volume/vapour); arterial pressure and blood gases were monitored throughout the protocol. After each cycle, the animal was stimulated with a foot clamp for 2 s. Mean arterial pressure (MAP:mmHg) response to this stimulation (percent change from the resting MAP) was used as an index of analgesia. Mean arterial pressure was significantly lower during ventilation with PFC:hal (73 +/- 7 SE) as compared with MAP during neat PFC (113 +/- 5 SE) or gas ventilation (107 +/- SE). Mean arterial pressure response (% change in MAP from baseline) to foot-clamp stimulation was significantly lower with PFC:hal ventilation (+ 12 +/- 5% SE) as compared with neat PFC (+ 28 +/- 8% SE) and gas ventilation (+ 29 +/- 9% SE). There was no statistically significant difference in resting MAP or MAP response to foot-clamp stimulation between cyc...Continue Reading

References

Apr 1, 1976·Pediatric Research·T H ShafferM Delivoria-Papadopoulos
Jul 1, 1990·The Journal of Pediatrics·J S GreenspanT H Shaffer
Sep 1, 1988·Pediatric Research·P A KoenT H Shaffer
Jan 1, 1986·The Journal of Surgical Research·D L FormanT H Shaffer
Apr 1, 1985·Anesthesia and Analgesia·R T ChilcoatW W Mapleson
Jan 1, 1980·Bioethics Quarterly·Daniel Steiner

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Citations

May 25, 2005·Paediatric Respiratory Reviews·Marla R Wolfson, Thomas H Shaffer
Feb 7, 2004·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Jürgen P MeinhardtRonald B Hirschl
Nov 24, 2001·American Journal of Respiratory and Critical Care Medicine·A R FranzH D Hummler
Nov 2, 2011·Oman Medical Journal·Qutaiba A Tawfic, Rajini Kausalya
May 11, 2007·Expert Opinion on Drug Delivery·Hans-Joachim Lehmler
Jan 14, 2004·Paediatric Anaesthesia·Marla R Wolfson, Thomas H Shaffer
Oct 14, 2010·Experimental Lung Research·Rolf DembinskiRalf Kuhlen
Apr 30, 1998·Annals of Medicine·C M WeisT H Shaffer
Nov 15, 2011·International Journal of Pharmaceutics·C TsagogiorgasM Quintel
Aug 26, 1998·Pediatric Pulmonology·M R WolfsonT H Shaffer
Mar 27, 2003·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Giuseppe A Marraro

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