PMID: 9523820Apr 2, 1998Paper

Halothane and isoflurane decrease alveolar epithelial fluid clearance in rats

Anesthesiology
S Rezaiguia-DelclauxP Duvaldestin

Abstract

Active sodium transport is the primary mechanism that drives alveolar fluid clearance. In the current study, the effects of exposure to halothane and isoflurane on alveolar fluid clearance in rats were evaluated. Rats were exposed to either halothane (0.4% for 6 h or 2% for 2 h) or isoflurane (0.6% for 6 h or 2.8% for 2 h). Reversibility of halothane effects was assessed after 2 h of exposure to 2% halothane. Alveolar and lung liquid clearance were measured by intratracheal instillation of a 5% albumin solution with 1.5 microCi of 125I-albumin, during mechanical ventilation with 100% FiO2 and the halogenated agent. The effect of terbutaline (10(-4) M) added to the albumin solution was tested after 2 h of exposure to 2% halothane. The increase in protein concentration in the airspaces over 1 h was used to evaluate alveolar liquid clearance. Lung liquid clearance was calculated gravimetrically. Alveolar liquid clearance rates were decreased by 24%, 30% and 40% compared with controls (P < 0.05) after 2 h of exposure to halothane, 6 h of exposure to halothane, and 6 h of exposure to isoflurane, respectively. After 2 h of exposure to isoflurane, alveolar liquid clearance did not change. In the 2-h halothane exposure group, alveolar ...Continue Reading

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Citations

Oct 10, 2002·Acta Anaesthesiologica Scandinavica·R S K TakalaR E Aantaa
Jan 31, 2002·Anesthesiology·Marc LaffonMichael A Matthay
Aug 18, 2009·American Journal of Physiology. Lung Cellular and Molecular Physiology·Erin N Z YuIan C Davis
Nov 30, 2010·American Journal of Physiology. Lung Cellular and Molecular Physiology·R Mac SweeneyD F McAuley
Apr 14, 2000·American Journal of Respiratory and Critical Care Medicine·V G NielsenS Matalon
May 10, 2003·American Journal of Respiratory and Critical Care Medicine·Makoto SugitaYves Berthiaume
Jul 29, 2010·Anesthesia and Analgesia·Michael A Matthay, Christian Jayr
Jun 24, 1998·Anesthesiology·J P Wiener-Kronish, M A Gropper
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Jan 8, 2014·Pulmonary Pharmacology & Therapeutics·Leonel MalacridaArturo Briva
Sep 10, 2016·American Journal of Respiratory and Critical Care Medicine·Matthieu JabaudonJean-Michel Constantin
Mar 31, 2012·Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews·James W Holder
Jan 10, 2006·Molecular Pharmacology·Antoine RochSarah Sariban-Sohraby
Jun 28, 2002·Physiological Reviews·Michael A MatthayChristine Clerici
Mar 4, 2000·Anaesthesia and Intensive Care·P P McConkey
Apr 14, 2020·Anesthesiology and Pain Medicine·Mohammad HajijafariMohammad Hossein Ziloochi
Aug 13, 1999·Journal of Applied Physiology·P D CharronM B Maron
May 29, 2000·Anesthesia and Analgesia·V G NielsenS Matalon
Dec 9, 1998·The American Journal of Physiology·V G NielsenS Matalon

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